Association Between Visceral Fat and Brain Cortical Thickness in the Elderly: A Neuroimaging Study.
MRI
abdominal fat
cortical thickness
neuroimaging
visceral fat
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
04
2021
accepted:
02
06
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Despite emerging evidence suggesting that visceral fat may play a major role in obesity-induced neurodegeneration, little evidence exists on the association between visceral fat and brain cortical thickness in the elderly. We aimed to examine the association between abdominal fat and brain cortical thickness in a Korean elderly population. This cross-sectional study included elderly individuals without dementia ( The mean (standard deviation) age was 67.6 (5.0) years. The highest quintile (vs. the middle quintile) group of visceral fat area had reduced cortical thicknesses in the global [β = -0.04 mm, standard error (SE) = 0.02 mm, The findings suggest that a high level of visceral fat, but not subcutaneous fat, is associated with a reduced cortical thickness in the elderly.
Sections du résumé
BACKGROUND
BACKGROUND
Despite emerging evidence suggesting that visceral fat may play a major role in obesity-induced neurodegeneration, little evidence exists on the association between visceral fat and brain cortical thickness in the elderly.
PURPOSE
OBJECTIVE
We aimed to examine the association between abdominal fat and brain cortical thickness in a Korean elderly population.
METHODS
METHODS
This cross-sectional study included elderly individuals without dementia (
RESULTS
RESULTS
The mean (standard deviation) age was 67.6 (5.0) years. The highest quintile (vs. the middle quintile) group of visceral fat area had reduced cortical thicknesses in the global [β = -0.04 mm, standard error (SE) = 0.02 mm,
CONCLUSION
CONCLUSIONS
The findings suggest that a high level of visceral fat, but not subcutaneous fat, is associated with a reduced cortical thickness in the elderly.
Identifiants
pubmed: 34248609
doi: 10.3389/fnagi.2021.694629
pmc: PMC8261238
doi:
Types de publication
Journal Article
Langues
eng
Pagination
694629Informations de copyright
Copyright © 2021 Cho, Seo, Kim, Kim and Noh.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Obes Rev. 2014 Jun;15(6):504-15
pubmed: 24661566
J Clin Endocrinol Metab. 2021 Mar 02;:
pubmed: 33677592
J Clin Invest. 2020 Apr 1;130(4):1961-1976
pubmed: 31935195
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Alzheimers Dement. 2018 May;14(5):601-609
pubmed: 29169013
J Psychiatr Res. 2009 Jan;43(4):411-31
pubmed: 18579155
Front Aging Neurosci. 2011 Sep 13;3:12
pubmed: 21949507
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Alzheimer Dis Assoc Disord. 2015 Oct-Dec;29(4):279-86
pubmed: 25626634
Neuroimage. 1999 Feb;9(2):195-207
pubmed: 9931269
Int J Obes (Lond). 2016 Jul;40(7):1177-82
pubmed: 27089992
Yonsei Med J. 2021 Mar;62(3):255-261
pubmed: 33635016
Obesity (Silver Spring). 2008 Jan;16(1):119-24
pubmed: 18223623
Int J Neurosci. 2008 Nov;118(11):1582-93
pubmed: 18853335
Lancet Diabetes Endocrinol. 2015 Jun;3(6):431-436
pubmed: 25866264
Obes Rev. 2008 May;9(3):204-18
pubmed: 18331422
Brain Behav Immun. 2015 Nov;50:221-231
pubmed: 26184082
Neurology. 2019 Feb 5;92(6):e594-e600
pubmed: 30626649
Hum Brain Mapp. 2010 Mar;31(3):353-64
pubmed: 19662657
Age Ageing. 2016 Jan;45(1):14-21
pubmed: 26764391
Lancet. 2008 Feb 16;371(9612):569-78
pubmed: 18280327
BMJ. 2003 Jan 25;326(7382):219
pubmed: 12543843
Arch Intern Med. 2007 Sep 10;167(16):1720-8
pubmed: 17846390
Cereb Cortex. 2018 Aug 1;28(8):2959-2975
pubmed: 29771288
Int J Obes (Lond). 2012 May;36(5):656-64
pubmed: 21894161
Obesity (Silver Spring). 2015 May;23(5):1092-6
pubmed: 25919926
Neuroimage. 2010 Oct 1;52(4):1215-23
pubmed: 20441796
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Ann Neurol. 2010 Aug;68(2):136-44
pubmed: 20695006
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
Neurology. 2009 Aug 11;73(6):457-65
pubmed: 19667321
Cereb Cortex. 2004 Jan;14(1):11-22
pubmed: 14654453
Radiology. 2019 Jun;291(3):763-771
pubmed: 31012815
Neuroimage. 2008 Jul 15;41(4):1177-83
pubmed: 18486492
JAMA Netw Open. 2019 Jun 5;2(6):e196126
pubmed: 31225892
Ann Neurol. 2019 Feb;85(2):194-203
pubmed: 30556596
Hum Brain Mapp. 2013 Jul;34(7):1737-46
pubmed: 22419507
Neuroimage. 2004;23 Suppl 1:S69-84
pubmed: 15501102