Prevention and Recovery of COVID-19 Patients With Kampo Medicine: Review of Case Reports and Ongoing Clinical Trials.
COVID-19
Japan society for oriental medicine
Kampo
SARS-CoV-2
prevention
recovery
treatment
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
01
2021
accepted:
31
05
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19) spread to Japan in 2020, where the number of infected patients exceeded 250,000 and COVID-related deaths exceeded 3,500 in one year. Basic guidelines for infection control were implemented in Japan, and research and development of effective drugs and vaccines were promoted. This included considering Kampo medicine, which has a long history of treating recurring emerging viral infections. Considering the characteristics of the disease (inflammation of the upper and lower respiratory tract as well as potential neural damage and vasculitis), Kampo medicine could be considered as a treatment strategy due to its antiviral and anti-inflammatory effects induced by multiple active substances that could aid in disease prevention and recovery. In this study, case reports on the management of COVID-19 with Kampo medicine, which were published until March 31, 2021, were reviewed. The search strategy involved the use of Medline and hand-searching. Twenty two patients were treated using Kampo medicines with or without Western medicine, based on individual conditions. On the other hand, the effects of Kampo medicines as a potential preventive treatment (pre-infection), active treatment (especially in the acute and subacute stage), or treatment of sequelae to aid recovery (after infection) in the different stages of COVID-19 are being studied as research projects in the Japan Society for Oriental Medicine (JSOM). JSOM has also organized a pioneering project of clinical trials for COVID-19, some of which are now in progress.
Identifiants
pubmed: 34248620
doi: 10.3389/fphar.2021.656246
pii: 656246
pmc: PMC8261067
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
656246Informations de copyright
Copyright © 2021 Takayama, Namiki, Odaguchi, Arita, Hisanaga, Mitani and Ito.
Déclaration de conflit d'intérêts
ST and TI belong to the Department of Kampo and Integrative Medicine, Tohoku University Graduate School of Medicine, a joint research course with TSUMURA and Co., which is a paratheatrical company of Kampo medicine in Japan. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Phytomedicine. 2020 Dec;79:153336
pubmed: 32949888
Geriatr Gerontol Int. 2017 May;17(5):679-688
pubmed: 27273639
Hypertens Res. 2014 Apr;37(4):253-390
pubmed: 24705419
Trials. 2020 Oct 2;21(1):827
pubmed: 33008479
Front Nutr. 2020 Jul 15;7:86
pubmed: 32766269
J Infect Chemother. 2012 Aug;18(4):534-43
pubmed: 22350323
JAMA. 2020 Aug 11;324(6):603-605
pubmed: 32644129
Tohoku J Exp Med. 2021;254(2):71-80
pubmed: 34108344
Nat Med. 2020 May;26(5):672-675
pubmed: 32296168
Front Public Health. 2020 Nov 23;8:590041
pubmed: 33330334
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Trials. 2021 Jan 6;22(1):23
pubmed: 33407828
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
BMC Complement Altern Med. 2019 Mar 18;19(1):68
pubmed: 30885188
Science. 2020 May 8;368(6491):
pubmed: 32234805
N Engl J Med. 2012 Nov 8;367(19):1814-20
pubmed: 23075143
Intern Med. 2020;59(14):1773-1775
pubmed: 32669517
Phytomedicine. 2021 May;85:153242
pubmed: 33867046
Phytomedicine. 2021 May;85:153531
pubmed: 33799224
Chin Med J (Engl). 2020 May 5;133(9):1087-1095
pubmed: 32358325
Front Nutr. 2018 Jul 23;5:66
pubmed: 30083536
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Int J Biol Sci. 2021 Jan 1;17(1):97-106
pubmed: 33390836
Respir Investig. 2013 Dec;51(4):260-77
pubmed: 24238235
Am J Respir Crit Care Med. 2020 Sep 15;202(6):812-821
pubmed: 32584597
JAMA. 2021 Feb 9;325(6):529-531
pubmed: 33404586