The SPARC DRC: Building a Resource for the Autonomic Nervous System Community.
FAIR
SPARC
autonomic nervous system
computational life sciences
data annotation
data curation
knowledge management
neural mapping
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
04
2021
accepted:
28
05
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, and simulation tools for the mammalian autonomic nervous system. The experimental data and mathematical models supplied to the DRC by the SPARC consortium are curated, annotated and semantically linked via a single knowledgebase. A data portal has been developed that allows discovery of data and models both via semantic search and via an interface that includes Google Map-like 2D flatmaps for displaying connectivity, and 3D anatomical organ scaffolds that provide a common coordinate framework for cross-species comparisons. We discuss examples that illustrate the data pipeline, which includes data upload, curation, segmentation (for image data), registration against the flatmaps and scaffolds, and finally display via the web portal, including the link to freely available online computational facilities that will enable neuromodulation hypotheses to be investigated by the autonomic neuroscience community and device manufacturers.
Identifiants
pubmed: 34248680
doi: 10.3389/fphys.2021.693735
pmc: PMC8265045
doi:
Types de publication
Journal Article
Langues
eng
Pagination
693735Informations de copyright
Copyright © 2021 Osanlouy, Bandrowski, de Bono, Brooks, Cassarà, Christie, Ebrahimi, Gillespie, Grethe, Guercio, Heal, Lin, Kuster, Martone, Neufeld, Nickerson, Soltani, Tappan, Wagenaar, Zhuang and Hunter.
Déclaration de conflit d'intérêts
AB, MM, and JG have equity interest in SciCrunch.com, a tech startup out of UCSD that develops tools and services for reproducible science, including support for RRIDs. AB is the CEO of SciCrunch.com. ST and MH are company employees of MBF Bioscience, a commercial entity. LG and JW were employed by Blackfynn Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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