Metabolic Control of Smoldering Neuroinflammation.
immunometabolism
macrophages
metabolism
microglia
mitochondria
progressive multiple sclerosis
smoldering inflammation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
05
2021
accepted:
31
05
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Compelling evidence exists that patients with chronic neurological conditions, which includes progressive multiple sclerosis, display pathological changes in neural metabolism and mitochondrial function. However, it is unknown if a similar degree of metabolic dysfunction occurs also in non-neural cells in the central nervous system. Specifically, it remains to be clarified (i) the full extent of metabolic changes in tissue-resident microglia and infiltrating macrophages after prolonged neuroinflammation (e.g., at the level of chronic active lesions), and (ii) whether these alterations underlie a unique pathogenic phenotype that is amenable for therapeutic targeting. Herein, we discuss how cell metabolism and mitochondrial function govern the function of chronic active microglia and macrophages brain infiltrates and identify new metabolic targets for therapeutic approaches aimed at reducing smoldering neuroinflammation.
Identifiants
pubmed: 34249016
doi: 10.3389/fimmu.2021.705920
pmc: PMC8262770
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
705920Subventions
Organisme : Wellcome Trust
ID : RG G105713
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Peruzzotti-Jametti, Willis, Hamel, Krzak and Pluchino.
Déclaration de conflit d'intérêts
SP is co-founder, CSO, and shareholder (>5%) of CITC Ltd. and iSTEM Therapeutics and co-founder and Non-Executive Director at Asitia Therapeutics; LP-J is a shareholder of CITC Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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