Analgesic and Anti-Inflammatory Effects of Hydroalcoholic and Hexane Extracts of
Acetic acid test
Smyrniopsis aucheri
analgesics
anti-inflammatory agents
carrageenan test
croton oil
formalin test
nociception tests
Journal
International journal of preventive medicine
ISSN: 2008-7802
Titre abrégé: Int J Prev Med
Pays: Iran
ID NLM: 101535380
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
09
2020
accepted:
09
03
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
The fruits of Apiaceae family have been widely used in traditional medicine for the treatment of pain and inflammation. In this study, we evaluated the analgesic and anti-inflammatory effects of wild celery ( Hydroalcoholic and hexane extracts of seeds were prepared and for the evaluation of analgesic activity, acetic acid, formalin, and hotplate tests in male mice (20-30 g) and for anti-inflammatory assessment carrageenan-induced paw edema in rats and croton oil-induced ear edema in mice were used. Hydroalcoholic and hexane extracts (100-400 mg/kg) significantly reduced abdominal spasms in the acetic acid test. In the formalin test, the hydroalcoholic extract at doses of 200 and 400 mg/kg reduced the pain of the chronic phase while hexane extract was effective in both acute and chronic phases. In the hot plate test, both extracts were ineffective. In the carrageenan and croton tests, both extracts at a dose of 400 mg/kg significantly reduced edema. The results revealed the analgesic and anti-inflammatory effects of plant seed extracts. Due to the lack of response of the extracts in the hot plate test, it seems that the plant mainly has a peripheral analgesic effect.
Sections du résumé
BACKGROUND
BACKGROUND
The fruits of Apiaceae family have been widely used in traditional medicine for the treatment of pain and inflammation. In this study, we evaluated the analgesic and anti-inflammatory effects of wild celery (
METHODS
METHODS
Hydroalcoholic and hexane extracts of seeds were prepared and for the evaluation of analgesic activity, acetic acid, formalin, and hotplate tests in male mice (20-30 g) and for anti-inflammatory assessment carrageenan-induced paw edema in rats and croton oil-induced ear edema in mice were used.
RESULTS
RESULTS
Hydroalcoholic and hexane extracts (100-400 mg/kg) significantly reduced abdominal spasms in the acetic acid test. In the formalin test, the hydroalcoholic extract at doses of 200 and 400 mg/kg reduced the pain of the chronic phase while hexane extract was effective in both acute and chronic phases. In the hot plate test, both extracts were ineffective. In the carrageenan and croton tests, both extracts at a dose of 400 mg/kg significantly reduced edema.
CONCLUSIONS
CONCLUSIONS
The results revealed the analgesic and anti-inflammatory effects of plant seed extracts. Due to the lack of response of the extracts in the hot plate test, it seems that the plant mainly has a peripheral analgesic effect.
Identifiants
pubmed: 34249289
doi: 10.4103/ijpvm.IJPVM_550_20
pii: IJPVM-12-40
pmc: PMC8218810
doi:
Types de publication
Journal Article
Langues
eng
Pagination
40Informations de copyright
Copyright: © 2021 International Journal of Preventive Medicine.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Iran J Pharm Res. 2012 Spring;11(2):679-88
pubmed: 24250493
Brain Res. 2001 Dec 7;921(1-2):233-9
pubmed: 11720731
Proc Soc Exp Biol Med. 1962 Dec;111:544-7
pubmed: 14001233
J Ethnopharmacol. 2007 Jan 19;109(2):226-8
pubmed: 17005345
Chem Pharm Bull (Tokyo). 1990 Apr;38(4):1045-8
pubmed: 2379278
J Neurosci. 1992 Sep;12(9):3665-70
pubmed: 1326610
Br J Pharmacol. 1973 May;48(1):88-96
pubmed: 4146764
Fitoterapia. 2004 Sep;75(6):557-65
pubmed: 15351109
Pharm Biol. 2011 Feb;49(2):146-51
pubmed: 20942602
Iran J Pharm Res. 2012 Fall;11(4):1169-74
pubmed: 24250550
Br J Pain. 2013 Nov;7(4):189-208
pubmed: 26516523
J Allergy Clin Immunol. 1999 Mar;103(3 Pt 2):S378-81
pubmed: 10069896
J Ethnopharmacol. 2002 Jul;81(2):211-5
pubmed: 12065153
Pharm Acta Helv. 1998 Aug;73(3):167-70
pubmed: 9713260
Inflamm Allergy Drug Targets. 2009 Jul;8(3):229-35
pubmed: 19601883
J Ethnopharmacol. 2009 Jul 30;124(3):475-80
pubmed: 19467316