Muscle weakness caused by cancer and chemotherapy is associated with loss of motor unit connectivity.
Cachexia
cancer
chemotherapy
motor unit
muscle weakness
Journal
American journal of cancer research
ISSN: 2156-6976
Titre abrégé: Am J Cancer Res
Pays: United States
ID NLM: 101549944
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
05
2021
accepted:
28
05
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Skeletal muscle wasting and weakness caused by cancer and its treatments (known as "cachexia") drastically impair quality of life and worsen survival outcomes in cancer patients. There are currently no approved treatments for cachexia. Hence, further investigation into the causes of cachexia induced by cancer and chemotherapy is warranted. Here, we sought to investigate skeletal muscle wasting, weakness and loss of motor unit function in mice bearing cancers or administered chemotherapeutics. Mice bearing colorectal cancers, including C26, MC38 and HCT116, and mice receiving the chemotherapeutics folfiri and cisplatin were assessed for
Types de publication
Journal Article
Langues
eng
Pagination
2990-3001Subventions
Organisme : NIAMS NIH HHS
ID : T32 AR065971
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
AJCR Copyright © 2021.
Déclaration de conflit d'intérêts
None.
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