Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies.
T lymphocytes
actin binding proteins
actin cytoskeleton remodeling
immune-related actinopathies
immunological synapse
primary immunodeficiencies
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
02
2021
accepted:
06
04
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes.
Identifiants
pubmed: 34249918
doi: 10.3389/fcell.2021.665519
pmc: PMC8266300
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
665519Informations de copyright
Copyright © 2021 Dupré, Boztug and Pfajfer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
EMBO J. 2020 Mar 2;39(5):e102783
pubmed: 31894880
J Exp Med. 2004 Oct 4;200(7):847-56
pubmed: 15466619
Nature. 2014 Mar 6;507(7490):118-23
pubmed: 24487619
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6585-E6594
pubmed: 28716933
J Exp Med. 2007 Sep 3;204(9):2031-8
pubmed: 17682067
Nat Rev Immunol. 2007 Feb;7(2):131-43
pubmed: 17259969
J Exp Med. 2005 Oct 17;202(8):1031-6
pubmed: 16216891
J Allergy Clin Immunol. 2016 Dec;138(6):1681-1689.e8
pubmed: 27405666
Cell Rep. 2018 Jan 23;22(4):979-991
pubmed: 29386139
Curr Biol. 2013 Jun 3;23(11):999-1006
pubmed: 23707428
Trends Immunol. 2006 Sep;27(9):421-7
pubmed: 16860609
J Clin Invest. 2012 Sep;122(9):3239-47
pubmed: 22850876
Nat Commun. 2016 Mar 18;7:10969
pubmed: 26987298
Science. 2006 Aug 11;313(5788):839-42
pubmed: 16902139
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4685-4690
pubmed: 28416675
Nat Immunol. 2009 Jun;10(6):627-35
pubmed: 19430478
Physiol Rev. 2014 Jan;94(1):235-63
pubmed: 24382887
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2241-6
pubmed: 24469820
Science. 2020 May 22;368(6493):897-901
pubmed: 32381591
Nat Rev Mol Cell Biol. 2017 Jun;18(6):389-401
pubmed: 28248322
EMBO Mol Med. 2018 Feb;10(2):188-199
pubmed: 29282224
J Cell Biol. 2002 Dec 23;159(6):993-1004
pubmed: 12499356
Immunity. 2008 Sep 19;29(3):414-22
pubmed: 18760640
J Cell Sci. 2013 Jan 1;126(Pt 1):1-7
pubmed: 23516326
Immunity. 2007 Feb;26(2):177-90
pubmed: 17306570
Immunology. 2012 Oct;137(2):183-96
pubmed: 22804504
Immunity. 2003 Jan;18(1):141-54
pubmed: 12530983
Nat Immunol. 2008 Apr;9(4):424-31
pubmed: 18345003
Mol Cell. 2002 Dec;10(6):1269-81
pubmed: 12504004
J Allergy Clin Immunol. 2018 Dec;142(6):1947-1955
pubmed: 29432774
Sci Adv. 2017 Jun 21;3(6):e1603032
pubmed: 28691087
J Cell Biol. 2007 Nov 19;179(4):733-46
pubmed: 18025306
Proc Natl Acad Sci U S A. 2014 May 6;111(18):6708-13
pubmed: 24760828
Sci Transl Med. 2010 Jun 23;2(37):37ra44
pubmed: 20574068
Nature. 2004 Jan 8;427(6970):154-9
pubmed: 14712275
J Extracell Vesicles. 2020 Jun 19;9(1):1759926
pubmed: 32939232
Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a002444
pubmed: 20702599
Immunol Rev. 2019 Jan;287(1):121-134
pubmed: 30565251
Immunol Rev. 2008 Feb;221:77-89
pubmed: 18275476
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14418-23
pubmed: 17726106
Immunity. 2001 Mar;14(3):315-29
pubmed: 11290340
Mol Cell Biol. 2017 Mar 31;37(8):
pubmed: 28137909
Nat Cell Biol. 2015 Nov;17(11):1435-45
pubmed: 26414403
Science. 1998 Dec 18;282(5397):2266-9
pubmed: 9856952
N Engl J Med. 2009 Nov 19;361(21):2046-55
pubmed: 19776401
Front Cell Dev Biol. 2020 Oct 21;8:591348
pubmed: 33195256
Nat Commun. 2018 May 22;9(1):2013
pubmed: 29789604
Immunity. 2008 Jun;28(6):810-21
pubmed: 18549800
J Exp Med. 2016 Oct 17;213(11):2413-2435
pubmed: 27647349
PLoS One. 2012;7(8):e44010
pubmed: 22952854
Sci Signal. 2014 Jun 24;7(331):ra60
pubmed: 24962707
EMBO J. 2019 Jun 3;38(11):
pubmed: 30902847
J Immunol. 2003 Jul 15;171(2):1023-34
pubmed: 12847276
Blood. 2003 Dec 1;102(12):3890-9
pubmed: 12907449
Curr Biol. 2006 Jan 10;16(1):24-34
pubmed: 16401421
PLoS One. 2013 Sep 09;8(9):e73874
pubmed: 24040101
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6073-8
pubmed: 23536289
J Clin Invest. 2016 Oct 3;126(10):3837-3851
pubmed: 27599296
J Cell Biol. 2015 Feb 16;208(4):475-91
pubmed: 25666810
Front Immunol. 2020 Mar 13;11:318
pubmed: 32231661
J Allergy Clin Immunol. 2005 Dec;116(6):1364-71
pubmed: 16337472
J Immunol. 2012 Apr 15;188(8):3686-99
pubmed: 22442443
J Exp Med. 2007 Feb 19;204(2):369-80
pubmed: 17296785
Elife. 2015 Mar 11;4:
pubmed: 25758716
Immunity. 2006 Jul;25(1):117-27
pubmed: 16860761
J Exp Med. 2016 Oct 17;213(11):2437-2457
pubmed: 27647348
Elife. 2017 Jan 31;6:
pubmed: 28112644
J Allergy Clin Immunol. 2009 Dec;124(6):1289-302.e4
pubmed: 20004785
Nat Immunol. 2016 Dec;17(12):1352-1360
pubmed: 27776107
J Allergy Clin Immunol. 2013 Jun;131(6):1594-603
pubmed: 23522482
Medicine (Baltimore). 2003 May;82(3):203-15
pubmed: 12792306
Mol Cell Biol. 2014 Dec 1;34(23):4343-54
pubmed: 25246631
Nature. 1998 Sep 3;395(6697):82-6
pubmed: 9738502
J Immunol. 2009 Jan 15;182(2):1021-32
pubmed: 19124745
Haematologica. 2011 Oct;96(10):1415-23
pubmed: 21659358
J Clin Invest. 2004 Jan;113(1):49-57
pubmed: 14702108
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5916-E5924
pubmed: 27647916
Science. 2013 Aug 23;341(6148):1233151
pubmed: 23845947
J Immunol. 2002 Apr 1;168(7):3235-41
pubmed: 11907077
J Cell Biol. 2012 Jun 11;197(6):775-87
pubmed: 22665519
PLoS One. 2008;3(10):e3467
pubmed: 18941544
Immunity. 2019 Jan 15;50(1):152-165.e8
pubmed: 30611611
Nat Commun. 2017 Apr 03;8:14816
pubmed: 28368018
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1593-8
pubmed: 17242350
J Clin Immunol. 2017 May;37(4):336-338
pubmed: 28378256
J Cell Biol. 1982 Oct;95(1):137-43
pubmed: 6982900
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11351-6
pubmed: 12177428
Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):926-31
pubmed: 17213309
Immunity. 2012 Aug 24;37(2):351-63
pubmed: 22683126
PLoS Biol. 2011 Sep;9(9):e1001152
pubmed: 21931537
J Exp Med. 2013 Nov 18;210(12):2721-37
pubmed: 24190432
Blood. 2007 Oct 1;110(7):2371-80
pubmed: 17515402
Blood. 2021 Apr 15;137(15):2033-2045
pubmed: 33513601
J Immunol. 2012 Sep 1;189(5):2159-68
pubmed: 22821962
Nat Immunol. 2008 Nov;9(11):1307-15
pubmed: 18836449
Nat Commun. 2019 Nov 22;10(1):5320
pubmed: 31757941
Immunity. 2001 Nov;15(5):739-50
pubmed: 11728336
Blood. 2016 Jun 23;127(25):3180-91
pubmed: 27170596
Biochim Biophys Acta. 2010 Feb;1803(2):152-63
pubmed: 20102729
Curr Opin Hematol. 2017 Jan;24(1):16-22
pubmed: 27749373
PLoS Biol. 2019 Jun 10;17(6):e3000317
pubmed: 31181075
Nat Immunol. 2009 May;10(5):531-9
pubmed: 19349987
J Immunol. 2003 Sep 1;171(5):2287-95
pubmed: 12928373
Nat Cell Biol. 2019 May;21(5):603-613
pubmed: 30988424
J Autoimmun. 2018 Nov;94:110-121
pubmed: 30061013
N Engl J Med. 2015 Jun 18;372(25):2409-22
pubmed: 26083206
J Immunol. 2017 Dec 15;199(12):4036-4045
pubmed: 29127144
Immunity. 2015 May 19;42(5):864-76
pubmed: 25992860
J Exp Med. 2011 Oct 24;208(11):2305-20
pubmed: 22006977
Nat Rev Mol Cell Biol. 2009 Jan;10(1):75-82
pubmed: 19197334
Nat Immunol. 2005 Jan;6(1):80-9
pubmed: 15558067
Cell. 2007 May 18;129(4):773-85
pubmed: 17512410
Immunol Cell Biol. 2019 Apr;97(4):389-402
pubmed: 30779216
Science. 2020 Jul 10;369(6500):202-207
pubmed: 32647003
J Biol Chem. 2007 Aug 24;282(34):25152-8
pubmed: 17595162
Blood. 2016 Oct 27;128(17):2135-2143
pubmed: 27557945
Blood. 2018 Nov 29;132(22):2362-2374
pubmed: 30254128
Curr Biol. 1998 Dec 17-31;8(25):1347-56
pubmed: 9889097
Nat Immunol. 2020 Oct;21(10):1232-1243
pubmed: 32929275
J Allergy Clin Immunol. 2006 Apr;117(4):725-38; quiz 739
pubmed: 16630926
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32766723
J Immunol. 2006 Nov 15;177(10):7451-61
pubmed: 17082665
Eur J Hum Genet. 2015 Feb;23(2):165-72
pubmed: 24781755
J Exp Med. 2019 Dec 2;216(12):2778-2799
pubmed: 31601675
Science. 2017 May 12;356(6338):
pubmed: 28495700
J Clin Invest. 2019 Mar 1;129(3):1047-1060
pubmed: 30521495
J Cell Sci. 2011 Sep 15;124(Pt 18):3118-26
pubmed: 21868368
Mol Biol Cell. 2016 Aug 15;27(16):2519-22
pubmed: 27528696
J Cell Biol. 2016 Nov 7;215(3):383-399
pubmed: 27799367
Elife. 2020 Jun 08;9:
pubmed: 32510333
J Allergy Clin Immunol. 2021 Mar 1;:
pubmed: 33662367
J Allergy Clin Immunol. 2019 Jun;143(6):2296-2299
pubmed: 30771411
Immunity. 1996 May;4(5):421-30
pubmed: 8630728
Nat Commun. 2017 Jan 23;8:14209
pubmed: 28112205
J Exp Med. 2012 Jan 16;209(1):29-34
pubmed: 22231303
J Allergy Clin Immunol. 2019 Oct;144(4):1122-1125.e6
pubmed: 31271789
Cold Spring Harb Perspect Biol. 2016 Aug 01;8(8):
pubmed: 26988969
Nature. 2006 Sep 28;443(7110):462-5
pubmed: 17006514
Immunity. 2001 Nov;15(5):715-28
pubmed: 11728334
J Exp Med. 2001 Dec 17;194(12):1777-87
pubmed: 11748279
Sci Signal. 2014 Apr 22;7(322):ra37
pubmed: 24757177
Sci Adv. 2020 Jan 01;6(1):eaay2432
pubmed: 31911947
Nat Rev Mol Cell Biol. 2010 Apr;11(4):276-87
pubmed: 20308985
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4654-9
pubmed: 10758162
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14671-6
pubmed: 9405671
Immunity. 2004 Sep;21(3):305-14
pubmed: 15357942
J Exp Med. 2017 Jan;214(1):59-71
pubmed: 27994071
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4310-4319
pubmed: 32041868
Cell. 2016 Jun 30;166(1):63-76
pubmed: 27293185
Sci Signal. 2016 Apr 19;9(424):rs3
pubmed: 27095595
Clin Immunol. 2007 Jul;124(1):41-8
pubmed: 17512803
Nat Immunol. 2013 Aug;14(8):858-66
pubmed: 23793062
Sci Signal. 2020 Sep 15;13(649):
pubmed: 32934075
Elife. 2019 Jul 03;8:
pubmed: 31268421
Mol Cell Biol. 2013 Mar;33(5):958-73
pubmed: 23275443
Eur J Cell Biol. 2006 Apr;85(3-4):295-304
pubmed: 16546573
Front Cell Dev Biol. 2018 Sep 19;6:116
pubmed: 30283780
J Cell Sci. 2019 Sep 4;133(5):
pubmed: 31413071
J Exp Med. 2010 Nov 22;207(12):2733-49
pubmed: 21041455
Cell. 1994 Aug 26;78(4):635-44
pubmed: 8069912
J Immunol. 2001 Apr 15;166(8):5245-9
pubmed: 11290809
J Allergy Clin Immunol. 2018 Nov;142(5):1589-1604.e11
pubmed: 29751004
Nat Immunol. 2006 Mar;7(3):247-55
pubmed: 16444260
Front Immunol. 2012 Aug 17;3:230
pubmed: 22912631
Blood. 2015 Sep 24;126(13):1527-35
pubmed: 26224645
Integr Biol (Camb). 2015 Oct;7(10):1272-84
pubmed: 26156536
Sci Immunol. 2020 Jul 10;5(49):
pubmed: 32646852
J Exp Med. 2007 Feb 19;204(2):381-91
pubmed: 17296786
J Allergy Clin Immunol. 2010 Feb;125(2):439-448.e8
pubmed: 20159256
Blood. 2017 Oct 26;130(17):1949-1953
pubmed: 28903942
Science. 2003 Nov 14;302(5648):1218-22
pubmed: 14512504
Annu Rev Immunol. 2019 Apr 26;37:201-224
pubmed: 30576253
J Clin Invest. 2006 Mar;116(3):703-14
pubmed: 16470246
J Allergy Clin Immunol. 2017 Jul;140(1):273-277.e10
pubmed: 27965109
Blood. 2016 Jun 9;127(23):2903-14
pubmed: 26912466
Mol Biol Cell. 2012 Mar;23(5):834-52
pubmed: 22219382
Curr Biol. 2003 Mar 4;13(5):384-93
pubmed: 12620186
Immunity. 2000 Sep;13(3):323-32
pubmed: 11021530
Nat Immunol. 2009 Nov;10(11):1185-92
pubmed: 19783989
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10474-9
pubmed: 22689994
Sci Immunol. 2019 Mar 22;4(33):
pubmed: 30902904
Mol Cell Biol. 2007 Sep;27(17):5986-6000
pubmed: 17591693
Nat Immunol. 2004 May;5(5):531-8
pubmed: 15064761
Front Immunol. 2018 Jan 18;9:25
pubmed: 29403502
Hum Mol Genet. 2002 Apr 15;11(8):961-9
pubmed: 11971877
Curr Biol. 2014 Mar 3;24(5):579-85
pubmed: 24560576
Eur J Immunol. 1998 Feb;28(2):716-29
pubmed: 9521082
Curr Biol. 2018 Feb 19;28(4):489-502.e9
pubmed: 29398219
Mol Syst Biol. 2020 Jul;16(7):e9524
pubmed: 32618424
J Immunol. 1993 Oct 15;151(8):4383-90
pubmed: 8409409
Curr Biol. 2014 Jul 21;24(14):1628-1635
pubmed: 25017211
Cell. 2016 Mar 24;165(1):100-110
pubmed: 26924577
Immunity. 2002 Aug;17(2):157-66
pubmed: 12196287
Immunity. 2002 Jan;16(1):111-21
pubmed: 11825570
Blood. 2003 Oct 15;102(8):2948-50
pubmed: 12829596
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20296-301
pubmed: 18077330
J Clin Invest. 2007 Feb;117(2):407-18
pubmed: 17218989
Immunity. 2001 Nov;15(5):691-701
pubmed: 11728332
Am J Med Genet A. 2015 Nov;167A(11):2822-5
pubmed: 26386261
PLoS Biol. 2011 Sep;9(9):e1001151
pubmed: 21931536
J Immunol. 2013 Apr 1;190(7):3661-9
pubmed: 23455509
Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12151-6
pubmed: 26371316
Mol Cell. 2009 Nov 13;36(3):512-24
pubmed: 19917258
J Allergy Clin Immunol. 2015 Nov;136(5):1150-62
pubmed: 26078103
J Clin Invest. 2019 Dec 2;129(12):5600-5614
pubmed: 31710310
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1517-22
pubmed: 25605925
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8697-702
pubmed: 11447283
Cell Rep. 2019 Mar 19;26(12):3369-3379.e5
pubmed: 30893608
Cell Rep. 2020 Mar 10;30(10):3434-3447.e6
pubmed: 32160548
Blood. 2001 Jan 1;97(1):33-8
pubmed: 11133739
Science. 1999 Jul 9;285(5425):221-7
pubmed: 10398592
Immunity. 2007 Jun;26(6):784-97
pubmed: 17570692
Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8693-8
pubmed: 10411937
J Leukoc Biol. 2014 Nov;96(5):713-27
pubmed: 25210148
J Cell Sci. 2014 Aug 1;127(Pt 15):3199-204
pubmed: 24951115
Blood. 2012 Apr 12;119(15):3458-68
pubmed: 22174160
Curr Biol. 2006 Dec 5;16(23):2337-44
pubmed: 17141616
J Cell Biol. 2016 Jun 6;213(5):535-42
pubmed: 27241914
EMBO J. 2010 Jul 21;29(14):2301-14
pubmed: 20551903
Nature. 1995 May 11;375(6527):148-51
pubmed: 7753171
Nat Commun. 2014 Nov 19;5:5360
pubmed: 25406581
PLoS One. 2010 Nov 12;5(11):e13970
pubmed: 21103055
J Immunol. 2004 Aug 1;173(3):1658-62
pubmed: 15265894
Nat Commun. 2019 Jul 15;10(1):3106
pubmed: 31308374
Mol Genet Genomic Med. 2016 Sep 17;4(6):604-616
pubmed: 27896283
J Leukoc Biol. 2010 Nov;88(5):1031-40
pubmed: 20689099
Cell. 1996 Mar 8;84(5):723-34
pubmed: 8625410