Understanding Immune Thrombocytopenia: Looking Out of the Box.

ITP syndrome autoimmunity cancer immune thrombocytopenia immunodeficiency overlap syndromes secondary ITP

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2021
Historique:
received: 01 10 2020
accepted: 28 05 2021
entrez: 12 7 2021
pubmed: 13 7 2021
medline: 13 7 2021
Statut: epublish

Résumé

The pathogenesis of immune thrombocytopenia (ITP) is increasingly being elucidated, and its etiology is becoming more frequently identified, leading to a diagnostic shift from primary to secondary ITP. The overlap between autoimmunity, immunodeficiency, and cancer is evident, implying more interdisciplinarity in daily care. This mini-review is based on an expert meeting on ITP organized by the Intercontinental Cooperative ITP Study Group and presents the challenges of hematologists in understanding and investigating "out of the box" concepts associated with ITP.

Identifiants

pubmed: 34249957
doi: 10.3389/fmed.2021.613192
pmc: PMC8266194
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

613192

Informations de copyright

Copyright © 2021 Schifferli, Cavalli, Godeau, Liebman, Recher, Imbach and Kühne.

Déclaration de conflit d'intérêts

AS: Amgen (research funds) and Novartis (advisory board). BG: served as an expert for Amgen, Novartis, Grifols, LFB, and Roche, and received grands for the research from Amgen. TK: Novartis (research funds), Amgen (research funds), and UCB biosciences (advisory board). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Alexandra Schifferli (A)

Department of Hematology/Oncology, University Children's Hospital Basel, Basel, Switzerland.
Intercontinental Cooperative Immune thrombocytopenia (ITP) Study Group, Basel, Switzerland.

Franco Cavalli (F)

Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Bertrand Godeau (B)

Centre de Référence des Cytopénies Auto-Immunes de l'Adulte, Service de Médecine Interne, CHU Henri Mondor, AP-HP, Université Paris-Est Créteil, Créteil, France.

Howard A Liebman (HA)

Jane Anne Nohl Division of Hematology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Mike Recher (M)

Medical Outpatient Clinic and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital and University Basel, Basel, Switzerland.

Paul Imbach (P)

Intercontinental Cooperative Immune thrombocytopenia (ITP) Study Group, Basel, Switzerland.

Thomas Kühne (T)

Department of Hematology/Oncology, University Children's Hospital Basel, Basel, Switzerland.
Intercontinental Cooperative Immune thrombocytopenia (ITP) Study Group, Basel, Switzerland.

Classifications MeSH