Recurrence of Cryoglobulinemia Secondary to Hepatitis C in a Patient with HCV RNA (-) Negative in the Serum.
Extrahepatic HCV manifestations
Membranoproliferative glomerulonephritis
Mixed cryoglobulinemia
Journal
Case reports in nephrology and dialysis
ISSN: 2296-9705
Titre abrégé: Case Rep Nephrol Dial
Pays: Switzerland
ID NLM: 101636294
Informations de publication
Date de publication:
Historique:
received:
16
11
2020
accepted:
28
02
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Hepatitis C virus infection is associated with many extrahepatic manifestations such as mixed cryoglobulinemia (MC). Renal manifestation of HCV infection might present as cryo-positive membranoproliferative glomerulonephritis (MPGN). First-line therapy includes antiviral treatment as the underlying infection leads to formation of immune complexes. After introducing direct-acting antiviral agents (DAAs) cure rates of HCV infection increased. Sustained virologic response (SVR) is defined as the absence of HCV RNA in serum by a sensitive test performed 12 or 24 weeks after the end of antiviral treatment. Although HCV RNA is undetectable in the serum, it may be present in hepatocytes and peripheral blood mononuclear cells (occult HCV infection). However, the impact of DAA treatment on occult HCV infection is not clear. We report a case of recurrence of MC with MPGN and development of lymphoproliferative disorder 2 years after achieving SVR.
Identifiants
pubmed: 34250027
doi: 10.1159/000515587
pii: cnd-0011-0110
pmc: PMC8255656
doi:
Types de publication
Case Reports
Langues
eng
Pagination
110-115Informations de copyright
Copyright © 2021 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
J Hepatol. 2005 May;42(5):632-8
pubmed: 15826710
Clin Res Hepatol Gastroenterol. 2013 Sep;37(4):334-9
pubmed: 23562337
J Infect Dis. 2004 Jan 1;189(1):7-14
pubmed: 14702147
Kidney Int Suppl (2011). 2018 Oct;8(3):91-165
pubmed: 30675443
J Clin Exp Hepatol. 2011 Dec;1(3):185-9
pubmed: 25755384
Am J Kidney Dis. 2013 Apr;61(4):623-37
pubmed: 23102733
Kidney Int. 2014 Sep;86(3):619-24
pubmed: 24646855
Am J Med. 2015 Sep;128(9):950-5
pubmed: 25837517
Am J Kidney Dis. 2017 Aug;70(2):301-304
pubmed: 28343737
J Gen Virol. 2005 Mar;86(Pt 3):657-666
pubmed: 15722526
Clin Exp Med. 2019 Aug;19(3):401-406
pubmed: 31127433