Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson's disease.
Cardiac autonomic modulation
Deceleration capacity of heart rate
Heart rate variability
Idiopathic Parkinson’s disease
Journal
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
ISSN: 1619-1560
Titre abrégé: Clin Auton Res
Pays: Germany
ID NLM: 9106549
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
05
03
2021
accepted:
22
06
2021
pubmed:
13
7
2021
medline:
15
12
2021
entrez:
12
7
2021
Statut:
ppublish
Résumé
Cardiac autonomic dysfunction in idiopathic Parkinson's disease (PD) manifests as reduced heart rate variability (HRV). In the present study, we explored the deceleration capacity of heart rate (DC) in patients with idiopathic PD, an advanced HRV marker that has proven clinical utility. Standard and advanced HRV measures derived from 7-min electrocardiograms in 20 idiopathic PD patients and 27 healthy controls were analyzed. HRV measures were compared using regression analysis, controlling for age, sex, and mean heart rate. Significantly reduced HRV was found only in the subcohort of PD patients older than 60 years. Low- frequency power and global HRV measures were lower in patients than in controls, but standard beat-to-beat HRV markers (i.e., rMSSD and high-frequency power) were not significantly different between groups. DC was significantly reduced in the subcohort of PD patients older than 60 years compared to controls. Deceleration-related oscillations of HRV were significantly reduced in the older PD patients compared to healthy controls, suggesting that short-term DC may be a sensitive marker of cardiac autonomic dysfunction in PD. DC may be complementary to traditional markers of short-term HRV for the evaluation of autonomic modulation in PD. Further study to examine the association between DC and cardiac adverse events in PD is needed to clarify the clinical relevance of DC in this population.
Identifiants
pubmed: 34251546
doi: 10.1007/s10286-021-00815-4
pii: 10.1007/s10286-021-00815-4
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
729-736Subventions
Organisme : NIOSH CDC HHS
ID : T42 OH008429
Pays : United States
Organisme : Michael J. Fox Foundation for Parkinson's Research
ID : MJFF 6896
Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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