Targeted Chemical Modifications Identify Key Features of Carbohydrate Assemblies and Generate Tailored Carbohydrate Materials.
carbohydrates
electron diffraction
electron tomography
site-specific modifications
supramolecular assemblies
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
15 Sep 2021
15 Sep 2021
Historique:
received:
17
06
2021
pubmed:
13
7
2021
medline:
18
9
2021
entrez:
12
7
2021
Statut:
ppublish
Résumé
The molecular level description of carbohydrate assemblies is hampered by their structural complexity and the lack of suitable analytical methods. Here, we employed systematic chemical modifications to identify key non-covalent interactions that triggered the supramolecular assembly of a disaccharide model. While some modifications disrupted the supramolecular organization, others were tolerated, delivering important information on the aggregation process. The screening identified new geometries, including nanotubes, and twisted ribbons that were characterized with electron tomography and electron diffraction (ED) methods. This work demonstrates that the combination of synthetic chemistry and ED methods is a powerful tool to draw correlations between the molecular structure and the nanoscale architecture of carbohydrate assemblies.
Identifiants
pubmed: 34251709
doi: 10.1002/chem.202102164
pmc: PMC8518775
doi:
Substances chimiques
Carbohydrates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13139-13143Subventions
Organisme : max-planck-gesellschaft
Organisme : bundesministerium für bildung und forschung
ID : 13XP5114
Organisme : deutsche forschungsgemeinschaft
ID : SFB 1449
Organisme : cdp glyco@alps
ID : ANR-15-IDEX-02
Organisme : nanobio-icmg platform
ID : FR 2607
Informations de copyright
© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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