Prognostic interplay of kidney function with sarcopenia, anemia, disability and cognitive impairment. The GLISTEN study.

Activities of Daily Living Aged Anemia / epidemiology Cognitive Dysfunction Glomerular Filtration Rate Humans Kidney Prognosis Sarcopenia / epidemiology
Geriatric assessment Hospital related Multimorbidities

Journal

European journal of internal medicine
ISSN: 1879-0828
Titre abrégé: Eur J Intern Med
Pays: Netherlands
ID NLM: 9003220

Informations de publication

Date de publication:
11 2021
Historique:
received: 22 02 2021
revised: 01 06 2021
accepted: 29 06 2021
pubmed: 14 7 2021
medline: 15 12 2021
entrez: 13 7 2021
Statut: ppublish

Résumé

Interactions between chronic kidney disease (CKD) and several comorbidities may potentially affect prognosis of older hospitalized patients. This study aims at evaluating the prognostic interactions between estimated glomerular filtration rate (eGFR), anemia, sarcopenia, functional and cognitive dysfunction, and 3-year mortality among older patients discharged from acute care hospitals. Our series consisted of 504 older adults enrolled in a multicenter observational study carried out in twelve Acute Geriatric and Internal Medicine wards throughout Italy. CKD was defined as an eGFR< 60 ml/min/1.73 m eGFR < 30 mL/min/1.73 m Interactions among study risk factors designed distinct risk profiles in older patients discharged from acute care hospitals, that may help identify patients needing targeted interventions and appropriate follow-up after discharge.

Sections du résumé

BACKGROUND
Interactions between chronic kidney disease (CKD) and several comorbidities may potentially affect prognosis of older hospitalized patients. This study aims at evaluating the prognostic interactions between estimated glomerular filtration rate (eGFR), anemia, sarcopenia, functional and cognitive dysfunction, and 3-year mortality among older patients discharged from acute care hospitals.
METHODS
Our series consisted of 504 older adults enrolled in a multicenter observational study carried out in twelve Acute Geriatric and Internal Medicine wards throughout Italy. CKD was defined as an eGFR< 60 ml/min/1.73 m
RESULTS
eGFR < 30 mL/min/1.73 m
CONCLUSIONS
Interactions among study risk factors designed distinct risk profiles in older patients discharged from acute care hospitals, that may help identify patients needing targeted interventions and appropriate follow-up after discharge.

Identifiants

DOI: 10.1016/j.ejim.2021.06.031 PMID: 34253448
pubmed: 34253448
pii: S0953-6205(21)00242-9
doi: 10.1016/j.ejim.2021.06.031
pii:
doi:

Types de publication

Journal Article Multicenter Study Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

57-63

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Luca Soraci (L)

Unit of Geriatric Medicine, IRCCS INRCA, Cosenza, Italy.

Francesco Corica (F)

Department of Clinical and Experimental Medicine, University of Messina, University of Messina, Messina, Italy. Electronic address: coricaf@unime.it.

Andrea Corsonello (A)

Unit of Geriatric Medicine, IRCCS INRCA, Cosenza, Italy; Unit of Geriatric Pharmacoepidemiology and Biostatistics, IRCCS INRCA, Ancona and Cosenza, Italy.

Francesca Remelli (F)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy; Center for Clinical Epidemiology, School of Medicine, University of Ferrara, Ferrara, Italy.

Pasquale Abete (P)

Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.

Giuseppe Bellelli (G)

School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy; Acute Geriatric Unit, S. Gerardo Hospital, Monza, Italy.

Mario Bo (M)

Section of Geriatrics, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Molinette, Turin, Italy.

Antonio Cherubini (A)

Geriatria, Accettazione Geriatrica e Centro di ricerca per l'invecchiamento, IRCCS INRCA, Ancona, Italy.

Mauro Di Bari (M)

Research Unit of Medicine of Aging, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Geriatric Intensive Care Unit, Department of Geriatrics and Medicine, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Marcello Maggio (M)

Department of Medicine and Surgery, Geriatric Rehabilitation Department, University of Parma, Parma, Italy.

Anna Maria Martone (AM)

Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of the Sacred Heart, Rome, Italy.

Maria Rosaria Rizzo (MR)

Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy.

Giovanna Maria Manca (GM)

UOC di Geriatria, Ospedale SS. Trinità ASL 8, Cagliari, Italy.

Andrea P Rossi (AP)

Department of Medicine, Geriatric Division, University of Verona, Verona, Italy.

Antonella Zambon (A)

Department of Statistics and Quantitative Methods, Unit of Biostatistics, Epidemiology and Public Health, University of Milan-Bicocca, Milan, Italy; IRCCS Istituto Auxologico Italiano, Biostatistics Unit, Milan, Italy.

Stefano Volpato (S)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy; Center for Clinical Epidemiology, School of Medicine, University of Ferrara, Ferrara, Italy.

Francesco Landi (F)

Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of the Sacred Heart, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Réadaptation › Activités de la vie quotidienne › Prognostic interplay of kidney function with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Prognostic interplay of kidney function with...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Anémie › Prognostic interplay of kidney function with...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Prognostic interplay of kidney function with...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Débit de filtration glomérulaire › Prognostic interplay of kidney function with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prognostic interplay of kidney function with...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Prognostic interplay of kidney function with...
questionsmedicales.fr › Diagnostic › Pronostic › Prognostic interplay of kidney function with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Sarcopénie › Prognostic interplay of kidney function with...