Adenocarcinoma
/ drug therapy
Animals
Cancer Vaccines
/ therapeutic use
Carcinoma, Non-Small-Cell Lung
/ drug therapy
Colonic Neoplasms
/ drug therapy
Disease Models, Animal
Female
Helicobacter Infections
/ complications
Helicobacter pylori
Humans
Immune Checkpoint Inhibitors
/ therapeutic use
Lung Neoplasms
/ drug therapy
Male
Mice
Mice, Inbred C57BL
Retrospective Studies
Helicobacter pylori
cancer
cancer immunobiology
immunotherapy
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
17
10
2020
accepted:
24
06
2021
pubmed:
14
7
2021
medline:
9
3
2022
entrez:
13
7
2021
Statut:
ppublish
Résumé
In this study, we determined whether Using mouse models, we evaluated whether immune checkpoint inhibitors or vaccine-based immunotherapies are effective in reducing tumour volumes of In mice engrafted with MC38 colon adenocarcinoma or B16-OVA melanoma cells, the tumour volumes of non-infected mice undergoing anticytotoxic T-lymphocyte-associated protein 4 and/or programmed death ligand 1 or anti-cancer vaccine treatments were significantly smaller than those of infected mice. We observed a decreased number and activation status of tumour-specific CD8 Our study unveils for the first time that the stomach microbiota affects the response to cancer immunotherapies and that
Identifiants
pubmed: 34253574
pii: gutjnl-2020-323392
doi: 10.1136/gutjnl-2020-323392
pmc: PMC8862014
doi:
Substances chimiques
Cancer Vaccines
0
Immune Checkpoint Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
457-466Informations de copyright
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: FG received honoraria for oral communication from Lilly, Sanofi, Amgen, and is an advisory board of Merck Serono, Amgen and Sanofi. The remaining authors declare no conflicts of interest.
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