Impact of COVID-19 and lockdown regarding blood transfusion.
COVID-19
blood donation
lockdown
transfusion
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
10
03
2021
received:
11
01
2021
accepted:
10
03
2021
pubmed:
14
7
2021
medline:
18
8
2021
entrez:
13
7
2021
Statut:
ppublish
Résumé
The outbreak of a SARS-CoV-2 resulted in a massive afflux of patients in hospital and intensive care units with many challenges. Blood transfusion was one of them regarding both blood banks (safety, collection, and stocks) and consumption (usual care and unknown specific demand of COVID-19 patients). The risk of mismatch was sufficient to plan blood transfusion restrictions if stocks became limited. Analyses of blood transfusion in a tertiary hospital and blood collection in the referring blood bank between February 24 and May 31, 2020. Withdrawal of elective surgery and non-urgent care and admission of 2291 COVID-19 patients reduced global activity by 33% but transfusion by 17% only. Only 237 (10.3) % of COVID-19 patients required blood transfusion, including 45 (2.0%) with acute bleeding. Lockdown and cancellation of mobile collection resulted in an 11% reduction in blood donation compared to 2019. The ratio of reduction in blood transfusion to blood donation remained positive and stocks were slightly enhanced. Reduction of admissions due to SARS-CoV-2 pandemic results only in a moderate decrease of blood transfusion. Incompressible blood transfusions concern urgent surgery, acute bleeding (including some patients with COVID-19, especially under high anticoagulation), or are supportive for chemotherapy-induced aplasia or chronic anemia. Lockdown results in a decrease of blood donation by cancellation of mobile donation but with little impact on a short period by mobilization of usual donors. No mismatch between demand and donation was evidenced and no planned restriction to blood transfusion was necessary.
Sections du résumé
BACKGROUND
The outbreak of a SARS-CoV-2 resulted in a massive afflux of patients in hospital and intensive care units with many challenges. Blood transfusion was one of them regarding both blood banks (safety, collection, and stocks) and consumption (usual care and unknown specific demand of COVID-19 patients). The risk of mismatch was sufficient to plan blood transfusion restrictions if stocks became limited.
STUDY DESIGN AND METHODS
Analyses of blood transfusion in a tertiary hospital and blood collection in the referring blood bank between February 24 and May 31, 2020.
RESULTS
Withdrawal of elective surgery and non-urgent care and admission of 2291 COVID-19 patients reduced global activity by 33% but transfusion by 17% only. Only 237 (10.3) % of COVID-19 patients required blood transfusion, including 45 (2.0%) with acute bleeding. Lockdown and cancellation of mobile collection resulted in an 11% reduction in blood donation compared to 2019. The ratio of reduction in blood transfusion to blood donation remained positive and stocks were slightly enhanced.
DISCUSSION
Reduction of admissions due to SARS-CoV-2 pandemic results only in a moderate decrease of blood transfusion. Incompressible blood transfusions concern urgent surgery, acute bleeding (including some patients with COVID-19, especially under high anticoagulation), or are supportive for chemotherapy-induced aplasia or chronic anemia. Lockdown results in a decrease of blood donation by cancellation of mobile donation but with little impact on a short period by mobilization of usual donors. No mismatch between demand and donation was evidenced and no planned restriction to blood transfusion was necessary.
Identifiants
pubmed: 34255374
doi: 10.1111/trf.16422
pmc: PMC8447413
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2327-2335Informations de copyright
© 2021 AABB.
Références
Anesthesiology. 2020 Jul;133(1):16-18
pubmed: 32550680
Blood Transfus. 2019 May;17(3):191-195
pubmed: 31246561
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Blood Rev. 2000 Jun;14(2):94-110
pubmed: 11012252
Crit Care. 2020 Sep 18;24(1):561
pubmed: 32948243
Transfus Clin Biol. 2021 Feb;28(1):16-24
pubmed: 33276150
Transfusion. 2021 Aug;61(8):2327-2335
pubmed: 34255374
J Thromb Haemost. 2020 May;18(5):1094-1099
pubmed: 32220112
Vox Sang. 1994;67(2):132-8
pubmed: 7801601
Transfus Med. 2019 Dec;29(6):434-441
pubmed: 31696565
Transfusion. 2020 Sep;60(9):2156-2158
pubmed: 32672371
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Lancet Haematol. 2020 Oct;7(10):e756-e764
pubmed: 32628911
Transfusion. 2020 Mar;60(3):525-534
pubmed: 32027031
Crit Care Med. 2020 Sep;48(9):1358-1364
pubmed: 32467443
Thromb Res. 2020 Dec;196:227-230
pubmed: 32916565
Transfusion. 2020 Jun;60(6):1334-1335
pubmed: 32542716
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Thromb Res. 2020 Jul;191:148-150
pubmed: 32381264
Lancet Respir Med. 2019 Feb;7(2):163-172
pubmed: 30642776
Transfusion. 2020 Sep;60(9):1919-1923
pubmed: 32583506
J Infect Public Health. 2020 Nov;13(11):1678-1679
pubmed: 32405329
Radiology. 2020 Sep;296(3):E186-E188
pubmed: 32324103
Crit Care. 2020 Jun 19;24(1):364
pubmed: 32560658
Lancet Haematol. 2020 Nov;7(11):e779-e782
pubmed: 33091347
Ann Hematol. 2021 Aug;100(8):2133-2134
pubmed: 33188469
Intensive Care Med. 2020 Jun;46(6):1089-1098
pubmed: 32367170
Radiology. 2020 Sep;296(3):E189-E191
pubmed: 32324102
Transfusion. 2018 Jan;58(1):52-59
pubmed: 29239484
Anaesth Crit Care Pain Med. 2020 Dec;39(6):731-732
pubmed: 33010489
Hematol Oncol Clin North Am. 2019 Oct;33(5):749-766
pubmed: 31466602
Can J Cardiol. 2020 Sep;36(9):1550-1553
pubmed: 32599018
Am J Respir Crit Care Med. 2020 Aug 1;202(3):460-463
pubmed: 32543208
Anaesthesia. 2020 Aug;75(8):1105-1113
pubmed: 32339260
Thromb Res. 2020 Jul;191:145-147
pubmed: 32291094
Chest. 2021 Jun;159(6):2417-2427
pubmed: 33465342
Science. 2020 May 29;368(6494):957
pubmed: 32467382
Transfusion. 2021 Mar;61(3):692-698
pubmed: 33215718
Transfusion. 2020 Sep;60(9):2038-2046
pubmed: 32666556
Transfusion. 2020 Nov;60(11):2661-2674
pubmed: 32815181
Transfus Med. 2005 Aug;15(4):269-76
pubmed: 16101804
Transfusion. 2009 Jun;49(6):1083-91
pubmed: 19309473
Blood. 2020 Jul 23;136(4):489-500
pubmed: 32492712