Early-life gut microbiota and its connection to metabolic health in children: Perspective on ecological drivers and need for quantitative approach.
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
31
03
2021
revised:
18
05
2021
accepted:
18
06
2021
pubmed:
14
7
2021
medline:
6
8
2021
entrez:
13
7
2021
Statut:
ppublish
Résumé
The colonisation and development of the gut microbiota has been implicated in paediatric metabolic disorders via its powerful effect on host metabolic and immune homeostasis. Here we summarise the evidence from human studies on the early gut microbiota and paediatric overweight and obesity. Manipulation of the early gut microbiota may represent a promising target for countering the burgeoning metabolic disorders in the paediatric population, provided the assembly patterns of microbiota and their health consequences can be decoded. Therefore, in this review, we pay particular attention to the important ecological drivers affecting the community dynamics of the early gut microbiota. We then discuss the knowledge gaps in commonly studied exposures linking the gut microbiota to metabolic disorders, especially regarding maternal factors and antibiotic use. This review also attempts to give directions for future studies aiming to identify predictive and corrective measures for paediatric metabolic disorders based on the gut microbiota. Gut microbiota; Metabolism; Paediatric overweight and obesity; Ecological driver; Dynamics; Infants.
Identifiants
pubmed: 34256346
pii: S2352-3964(21)00268-1
doi: 10.1016/j.ebiom.2021.103475
pmc: PMC8324810
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103475Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
Références
Microbiome. 2017 Sep 4;5(1):113
pubmed: 28870230
Sci Adv. 2017 Oct 11;3(10):eaao1874
pubmed: 29026883
mSphere. 2018 Mar 7;3(2):
pubmed: 29564397
BMC Pediatr. 2013 Mar 25;13:40
pubmed: 23530957
Diabetologia. 2007 Nov;50(11):2374-83
pubmed: 17823788
JAMA Pediatr. 2018 Apr 1;172(4):368-377
pubmed: 29459942
Gut Microbes. 2021 Jan-Dec;13(1):1-15
pubmed: 33382954
Sci Rep. 2018 Oct 11;8(1):15113
pubmed: 30310162
Horm Res Paediatr. 2018;90(6):358-367
pubmed: 30739117
Appl Microbiol Biotechnol. 2014 Jul;98(13):6051-60
pubmed: 24687755
Pediatrics. 2015 Apr;135(4):617-26
pubmed: 25825533
Pediatr Res. 2020 Sep;88(3):438-443
pubmed: 31954376
Curr Nutr Rep. 2018 Dec;7(4):198-206
pubmed: 30264354
Gut Pathog. 2011 May 23;3(1):8
pubmed: 21605455
PLoS Med. 2019 Dec 6;16(12):e1002996
pubmed: 31809506
Front Microbiol. 2014 Jul 02;5:334
pubmed: 25071747
J Hepatol. 2014 Apr;60(4):824-31
pubmed: 24316517
Clin Exp Allergy. 2009 Dec;39(12):1842-51
pubmed: 19735274
Genome Biol. 2019 Jun 13;20(1):121
pubmed: 31196170
Curr Opin Microbiol. 2018 Aug;44:70-78
pubmed: 30086431
Pediatr Res. 2021 Jan;89(2):301-306
pubmed: 32919391
Mayo Clin Proc. 2021 Jan;96(1):66-77
pubmed: 33208243
Obes Res Clin Pract. 2020 May - Jun;14(3):197-204
pubmed: 32546361
Sci Rep. 2021 Jan 21;11(1):1472
pubmed: 33479326
Front Med (Lausanne). 2018 May 04;5:135
pubmed: 29780807
Cell. 2016 Jun 2;165(6):1551
pubmed: 27259157
Antimicrob Agents Chemother. 2012 Nov;56(11):5811-20
pubmed: 22948872
Pediatr Obes. 2020 Nov;15(11):e12680
pubmed: 32638554
Am J Clin Nutr. 2008 Mar;87(3):534-8
pubmed: 18326589
JAMA Netw Open. 2020 Dec 1;3(12):e2030415
pubmed: 33346848
J Dev Orig Health Dis. 2020 Jun;11(3):201-210
pubmed: 31601287
Nat Med. 2016 Jul 7;22(7):713-22
pubmed: 27387886
Cell Host Microbe. 2015 May 13;17(5):690-703
pubmed: 25974306
Trends Microbiol. 2019 Feb;27(2):131-147
pubmed: 30529020
Nat Commun. 2016 Jan 26;7:10410
pubmed: 26811868
Nat Commun. 2018 Oct 9;9(1):4169
pubmed: 30301893
Front Physiol. 2019 Mar 14;10:185
pubmed: 30923502
BMC Med. 2019 Nov 25;17(1):212
pubmed: 31760948
Science. 2020 Feb 28;367(6481):
pubmed: 32108090
Ann Hepatol. 2017 Oct 28;16(Suppl. 1: s3-105.):s4-s14
pubmed: 29080336
Adv Nutr. 2020 Jan 1;11(1):35-40
pubmed: 31612908
Acta Paediatr. 2015 Dec;104(467):30-7
pubmed: 26192560
BMC Pediatr. 2019 Jan 16;19(1):23
pubmed: 30651086
Curr Opin Microbiol. 2018 Aug;44:41-49
pubmed: 30041083
Open Biol. 2019 Sep 27;9(9):190128
pubmed: 31506017
Obes Rev. 2018 Nov;19(11):1463-1475
pubmed: 30035851
Nat Commun. 2020 Jul 23;11(1):3692
pubmed: 32703946
PLoS One. 2014 Feb 26;9(2):e87896
pubmed: 24586295
J Hepatol. 2017 Sep;67(3):568-576
pubmed: 28619255
Cell Rep Med. 2020 Dec 22;1(9):100156
pubmed: 33377127
Cancer Res. 1981 Sep;41(9 Pt 2):3766-8
pubmed: 6266664
Obes Rev. 2014 Oct;15(10):839-50
pubmed: 25132280
PLoS One. 2020 Jan 15;15(1):e0227285
pubmed: 31940382
Acta Paediatr. 2021 Jan;110(1):60-67
pubmed: 33405258
Int J Obes (Lond). 2013 Jul;37(7):893-9
pubmed: 23207407
J Infect. 2020 Aug;81(2):190-204
pubmed: 32389786
Sci Rep. 2018 Sep 13;8(1):13757
pubmed: 30214024
Microbiol Mol Biol Rev. 2017 Nov 8;81(4):
pubmed: 29118049
Microbiome. 2021 Jan 12;9(1):5
pubmed: 33436093
Obes Rev. 2007 Sep;8(5):385-94
pubmed: 17716296
BMC Public Health. 2014 Dec 13;14:1267
pubmed: 25495402
Cell. 2018 Nov 1;175(4):947-961.e17
pubmed: 30401435
PLoS One. 2021 Feb 8;16(2):e0246839
pubmed: 33556125
Sci Adv. 2019 Dec 11;5(12):eaax5727
pubmed: 31844663
mSystems. 2017 Sep 5;2(5):
pubmed: 28904999
FEMS Microbiol Ecol. 2020 May 1;96(5):
pubmed: 32275305
J Obes. 2012;2012:123023
pubmed: 22675610
Pediatrics. 2019 Feb;143(2):
pubmed: 30622156
mBio. 2018 Oct 23;9(5):
pubmed: 30352933
EMBO Rep. 2012 May 01;13(5):440-7
pubmed: 22422004
J Exp Med. 2006 Apr 17;203(4):973-84
pubmed: 16606665
JAMA Netw Open. 2018 Nov 2;1(7):e185025
pubmed: 30646378
Am J Clin Nutr. 2015 Dec;102(6):1381-8
pubmed: 26511224
Science. 2015 Sep 4;349(6252):1101-1106
pubmed: 26229116
Hepatol Commun. 2020 Aug 09;4(10):1392-1403
pubmed: 33024911
Nat Commun. 2018 Nov 30;9(1):5091
pubmed: 30504906
Dig Dis Sci. 2020 Mar;65(3):706-722
pubmed: 32002758
Br J Nutr. 2013 Jul 14;110(1):116-26
pubmed: 23228571
Science. 2016 Mar 18;351(6279):1296-302
pubmed: 26989247
Microorganisms. 2020 Dec 22;9(1):
pubmed: 33375064
NPJ Syst Biol Appl. 2017 Jan 31;3:3
pubmed: 28649430
Front Microbiol. 2019 May 31;10:1206
pubmed: 31214145
Nutrients. 2015 Mar 31;7(4):2237-60
pubmed: 25835047
Nat Rev Gastroenterol Hepatol. 2018 Apr;15(4):197-205
pubmed: 29362469
Pediatrics. 2019 Sep;144(3):
pubmed: 31431481
Microbiome. 2015 Oct 12;3:44
pubmed: 26455879
JAMA Pediatr. 2018 Jul 2;172(7):e181161
pubmed: 29868719
Biosci Rep. 2018 Apr 13;38(2):
pubmed: 29208770
Science. 2012 Apr 27;336(6080):489-93
pubmed: 22442383
Diabetes. 2007 Jul;56(7):1761-72
pubmed: 17456850
Int J Obes (Lond). 2010 Oct;34(10):1531-7
pubmed: 20231842
ISME J. 2018 Jun;12(7):1642-1657
pubmed: 29434314
mBio. 2020 Oct 13;11(5):
pubmed: 33051365
J Endocrinol. 2017 Oct;235(1):R1-R12
pubmed: 28751453
Microbiome. 2017 Mar 3;5(1):26
pubmed: 28253911
J Biosci. 2019 Oct;44(5):
pubmed: 31719225
Nat Microbiol. 2019 Mar;4(3):470-479
pubmed: 30559407
Gut Microbes. 2020;11(2):205-216
pubmed: 31550982
Nature. 2012 Aug 30;488(7413):621-6
pubmed: 22914093
Clin Nutr. 2021 Jan;40(1):207-216
pubmed: 32536582
Trends Microbiol. 2019 Dec;27(12):997-1010
pubmed: 31474424
Cell Host Microbe. 2018 Jul 11;24(1):133-145.e5
pubmed: 30001516
Nature. 2021 Mar;591(7851):633-638
pubmed: 33627867
Cell. 2014 Aug 14;158(4):705-721
pubmed: 25126780
Trends Mol Med. 2015 Feb;21(2):109-17
pubmed: 25578246
Nature. 2017 Nov 23;551(7681):507-511
pubmed: 29143816
Child Obes. 2020 Apr;16(3):204-210
pubmed: 31934770
Int J Obes (Lond). 2013 Oct;37(10):1295-306
pubmed: 23736360
Nat Commun. 2018 Jun 8;9(1):2233
pubmed: 29884786
BMJ. 2014 Apr 15;348:g2267
pubmed: 24735883
Int J Med Microbiol. 2021 Apr;311(3):151483
pubmed: 33689953
Elife. 2018 Sep 18;7:
pubmed: 30226190
BJOG. 2020 Jan;127(2):217-227
pubmed: 31006170
Nat Rev Immunol. 2017 Jul 27;17(8):461-463
pubmed: 28749457
Nat Metab. 2019 Jan;1(1):34-46
pubmed: 32694818
Lancet. 2018 May 5;391(10132):1830-1841
pubmed: 29673873
Eur J Nutr. 2015 Apr;54(3):355-63
pubmed: 24830782
JAMA Pediatr. 2016 Aug 1;170(8):750-7
pubmed: 27294842
BMC Microbiol. 2020 Mar 11;20(1):56
pubmed: 32160858
Nat Commun. 2021 Jan 26;12(1):443
pubmed: 33500411
Nature. 2019 Oct;574(7776):117-121
pubmed: 31534227
Protein Cell. 2018 May;9(5):397-403
pubmed: 29725936
Front Immunol. 2012 Jun 13;3:154
pubmed: 22707952
Nature. 2019 May;569(7758):663-671
pubmed: 31142858
Gut Microbes. 2020 Jul 3;11(4):962-978
pubmed: 32167021
Pediatrics. 2015 Jan;135(1):e92-8
pubmed: 25452656
Am J Clin Nutr. 2020 Apr 1;111(4):769-778
pubmed: 32068776
Curr Microbiol. 1995 Jul;31(1):23-7
pubmed: 7767225
Nat Commun. 2018 Oct 26;9(1):4462
pubmed: 30367045
Annu Rev Food Sci Technol. 2018 Mar 25;9:429-450
pubmed: 29580136
Nutr Metab Insights. 2015 Dec 16;8(Suppl 1):1-9
pubmed: 26715853
Cell. 2020 Oct 15;183(2):324-334.e5
pubmed: 33007265
EBioMedicine. 2020 May;55:102766
pubmed: 32408110