Prediction of quality of life in early breast cancer upon completion of adjuvant chemotherapy.
Journal
NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891
Informations de publication
Date de publication:
13 Jul 2021
13 Jul 2021
Historique:
received:
10
01
2021
accepted:
09
06
2021
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
15
7
2021
Statut:
epublish
Résumé
Quality of life (QoL) is a complex, ordinal endpoint with multiple conditioning factors. A predictive model of QoL after adjuvant chemotherapy can support decision making or the communication of information about the range of treatment options available. Patients with localized breast cancer (n = 219) were prospectively recruited at 17 centers. Participants completed the EORTC QLQ-C30 questionnaire. The primary aim was to predict health status upon completion of adjuvant chemotherapy adjusted for multiple covariates. We developed a Bayesian model with six covariates (chemotherapy regimen, TNM stage, axillary lymph node dissection, perceived risk of recurrence, age, type of surgery, and baseline EORTC scores). This model allows both prediction and causal inference. The patients with mastectomy reported a discrete decline on all QoL scores. The effect of surgery depended on the interaction with age. Women with ages on either end of the range displayed worse scores, especially with mastectomy. The perceived risk of recurrence had a striking effect on health status. In conclusion, we have developed a predictive model of health status in patients with early breast cancer based on the individual's profile.
Identifiants
pubmed: 34257315
doi: 10.1038/s41523-021-00296-8
pii: 10.1038/s41523-021-00296-8
pmc: PMC8277774
doi:
Types de publication
Journal Article
Langues
eng
Pagination
92Informations de copyright
© 2021. The Author(s).
Références
BMC Med Res Methodol. 2017 Sep 26;17(1):148
pubmed: 28950850
Clin Transl Oncol. 2019 Aug;21(8):1104-1107
pubmed: 30712235
Cancer. 2013 Apr 1;119(7):1402-11
pubmed: 23359049
Breast Cancer Res Treat. 2017 Jun;163(3):517-526
pubmed: 28324266
J Natl Cancer Inst. 1993 Mar 3;85(5):365-76
pubmed: 8433390
N Engl J Med. 2018 Jul 12;379(2):111-121
pubmed: 29860917
Stat Med. 1993 Aug;12(15-16):1501-11; discussion 1513-7
pubmed: 8248659
J Clin Epidemiol. 1997 Jan;50(1):45-55
pubmed: 9048689
PLoS One. 2013;8(4):e60684
pubmed: 23560103
Eur J Cancer. 2005 Sep;41(14):2120-31
pubmed: 16182120
J Clin Epidemiol. 1997 Apr;50(4):441-50
pubmed: 9179103
Eur J Surg Oncol. 2005 Oct;31(8):817-23
pubmed: 16043322
Lancet Respir Med. 2017 Jun;5(6):500-511
pubmed: 28522352
Breast Cancer Res Treat. 2005 Aug;92(3):217-22
pubmed: 16155792
N Engl J Med. 2002 Oct 17;347(16):1227-32
pubmed: 12393819
BMJ. 2015 Oct 06;351:h4901
pubmed: 26442924
Cad Saude Publica. 2008;24 Suppl 4:s581-91
pubmed: 18797732
Asia Pac J Oncol Nurs. 2014 Apr-Jun;1(1):22-32
pubmed: 27981079
Ann Surg Oncol. 2017 May;24(5):1242-1250
pubmed: 28000076
JAMA. 2020 Dec 1;324(21):2165-2176
pubmed: 33165621
Eur J Cancer. 1995 Dec;31A(13-14):2260-3
pubmed: 8652253
Soc Sci Res. 2012 Jan;41(1):182-98
pubmed: 23017706
Support Care Cancer. 2018 May;26(5):1411-1418
pubmed: 29143135
J Pain Symptom Manage. 2017 Apr;53(4):703-710
pubmed: 28042076
Eur J Cancer Care (Engl). 2012 Sep;21(5):684-91
pubmed: 22329843
J Clin Epidemiol. 2008 May;61(5):475-80
pubmed: 18394541
Health Psychol. 1997 May;16(3):284-98
pubmed: 9152708
Clin Transl Oncol. 2018 Nov;20(11):1408-1415
pubmed: 29651672
Asian Pac J Cancer Prev. 2014;15(13):5377-81
pubmed: 25041005
Cancer Metastasis Rev. 2015 Sep;34(3):381-400
pubmed: 26245646
Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):656-63
pubmed: 19190157
Cancer. 1992 Apr 15;69(8):2111-5
pubmed: 1544117
Jpn J Clin Oncol. 2014 Jan;44(1):22-7
pubmed: 24277749
Stat Methods Med Res. 2002 Feb;11(1):49-67
pubmed: 11923993
Health Qual Life Outcomes. 2014 Dec 31;12:192
pubmed: 25551580
Int J Environ Res Public Health. 2019 Dec 06;16(24):
pubmed: 31817811
Br J Cancer. 2017 Jun 6;116(12):1526-1535
pubmed: 28463962
Epidemiol Rev. 2011;33:165-75
pubmed: 21697257
Jpn J Clin Oncol. 2017 Oct 1;47(10):909-918
pubmed: 28981734
Am J Epidemiol. 2013 Feb 15;177(4):292-8
pubmed: 23371353
Ann Oncol. 2017 Oct 1;28(10):2340-2366
pubmed: 28945867
Surg Oncol. 2019 Dec;31:26-32
pubmed: 31493647
Eur J Surg Oncol. 2018 Jul;44(7):963-968
pubmed: 29678302
Clin Transl Oncol. 2017 Nov;19(11):1312-1319
pubmed: 28497424
J Clin Epidemiol. 2016 Jan;69:79-88
pubmed: 26327487
Eur J Cancer. 2009 Feb;45(3):347-53
pubmed: 19013787
Qual Life Res. 2014 Apr;23(3):971-6
pubmed: 24097080
Ann Oncol. 2017 Sep 1;28(9):2077-2085
pubmed: 28430862