Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution.
CLL
SARS-CoV-2
persistent infection
viral evolution
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
06
04
2021
accepted:
03
06
2021
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
15
7
2021
Statut:
epublish
Résumé
We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.
Identifiants
pubmed: 34258320
doi: 10.1093/ofid/ofab295
pii: ofab295
pmc: PMC8244814
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofab295Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Références
EBioMedicine. 2021 Feb;64:103230
pubmed: 33530000
Cell. 2020 Oct 1;183(1):158-168.e14
pubmed: 32979941
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
Curr Hematol Malig Rep. 2012 Mar;7(1):13-20
pubmed: 22231031
J Clin Virol. 2020 Aug;129:104468
pubmed: 32485620
Cell. 2020 Dec 23;183(7):1901-1912.e9
pubmed: 33248470
Cell Rep. 2021 Jun 29;35(13):109292
pubmed: 34166617
Nature. 2020 Aug;584(7819):115-119
pubmed: 32454513
EBioMedicine. 2021 Jun;68:103410
pubmed: 34098342
Blood. 2015 Jul 30;126(5):573-81
pubmed: 26084672
Nature. 2021 Apr;592(7853):277-282
pubmed: 33545711
Elife. 2020 Oct 28;9:
pubmed: 33112236
Nature. 2020 Aug;584(7821):457-462
pubmed: 32668444
Blood. 2020 Nov 12;136(20):2290-2295
pubmed: 32959052
Int J Mol Sci. 2020 Mar 06;21(5):
pubmed: 32155826
N Engl J Med. 2020 Dec 3;383(23):2291-2293
pubmed: 33176080
Nature. 2021 May;593(7857):130-135
pubmed: 33684923
Science. 2021 Mar 12;371(6534):1139-1142
pubmed: 33536258
Cell. 2021 Apr 29;184(9):2332-2347.e16
pubmed: 33761326