Registration of histopathology to magnetic resonance imaging of prostate cancer.
Histopathology correlation
Image registration
PET/MRI
Prostate cancer
Journal
Physics and imaging in radiation oncology
ISSN: 2405-6316
Titre abrégé: Phys Imaging Radiat Oncol
Pays: Netherlands
ID NLM: 101704276
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
04
12
2020
revised:
16
02
2021
accepted:
25
03
2021
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
15
7
2021
Statut:
epublish
Résumé
The diagnostic accuracy of new imaging techniques requires validation, preferably by histopathological verification. The aim of this study was to develop and present a registration procedure between histopathology and For twenty-five prostate cancer patients, planned for radical prostatectomy, a 3D-printed prostate mold based on Eighty-four landmarks were identified, located in the urethra (62%), prostatic cysts (33%), and the ejaculatory ducts (5%). The median number of landmarks was 3 per patient. We showed a median in-plane error of 1.8 mm before and 1.7 mm after the contour-correcting deformable registration. In patients with extraprostatic margins, the median in-plane error improved from 2.1 mm to 1.8 mm after the contour-correcting deformable registration. Our registration procedure accurately registers histopathology to
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
The diagnostic accuracy of new imaging techniques requires validation, preferably by histopathological verification. The aim of this study was to develop and present a registration procedure between histopathology and
MATERIALS AND METHODS
METHODS
For twenty-five prostate cancer patients, planned for radical prostatectomy, a 3D-printed prostate mold based on
RESULTS
RESULTS
Eighty-four landmarks were identified, located in the urethra (62%), prostatic cysts (33%), and the ejaculatory ducts (5%). The median number of landmarks was 3 per patient. We showed a median in-plane error of 1.8 mm before and 1.7 mm after the contour-correcting deformable registration. In patients with extraprostatic margins, the median in-plane error improved from 2.1 mm to 1.8 mm after the contour-correcting deformable registration.
CONCLUSIONS
CONCLUSIONS
Our registration procedure accurately registers histopathology to
Identifiants
pubmed: 34258403
doi: 10.1016/j.phro.2021.03.004
pii: S2405-6316(21)00018-X
pmc: PMC8254194
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19-25Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Authors Joakim Jonsson and Tufve Nyholm are part owners in Nonpi Medical AB. All other co-authors have no potential competing interest to report.
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