The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43.
Biological sciences
Cellular neuroscience
Molecular neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
23 Jul 2021
23 Jul 2021
Historique:
received:
10
09
2020
revised:
06
04
2021
accepted:
14
06
2021
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
15
7
2021
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease characterized by the formation of cytoplasmic ubiquitinated TDP-43 protein aggregates in motor neurons. Stress granules (SGs) are stress-induced cytoplasmic protein aggregates containing various neuropathogenic proteins, including TDP-43. Several studies have suggested that SGs are the initial site of the formation of pathogenic ubiquitinated TDP-43 aggregates in ALS neurons. Mutations in the
Identifiants
pubmed: 34258561
doi: 10.1016/j.isci.2021.102733
pii: S2589-0042(21)00701-X
pmc: PMC8259439
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102733Informations de copyright
© 2021.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest in association with the present study.
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