Systemic acidemia impairs cardiac function in critically Ill patients.
ABG-a
Acidemia
Acidosis
CFI
CI
CO
CPI
Cardiac contractility
Cardiac function
Critical care
GEF
PiCCO
Point-of-Care arterial blood gas
SVI
Transpulmonary thermodilution
dPmx
pH
Journal
EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
21
12
2020
revised:
29
04
2021
accepted:
24
05
2021
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
15
7
2021
Statut:
epublish
Résumé
Acidemia, is associated with reduced cardiac function in animals, but no studies showing an effect of acidemia on cardiac function in humans are reported. In the present study, we examined the effect of acidemia on cardiac function assessed with transpulmonary thermodilution technique with integrated pulse contour analysis (Pulse Contour Cardiac Output, PiCCO™) in a large cohort of critically ill patients. This was a prospective multicenter observational cross-sectional study of 297 patients from 6 intensive care units in London, England selected from all patients admitted consecutively between May 2018 and March 2019. Measurements of lowest plasma pH and concurrent assessment of cardiac function were obtained. There was a significant difference between two pH categories (pH ≤ 7.28 vs. pH > 7.28) for the following variables of cardiac function: SVI (difference in means 32.7; 95% CI: 21 to 45 mL/m2; Acidemia is associated with impaired cardiac function in seriously ill patients hospitalized in the intensive care unit supporting the potential value of early diagnosis and improvement of arterial pH in these patients. The study was partially supported by unrestricted funds from the UCLA School of Medicine.
Sections du résumé
BACKGROUND
BACKGROUND
Acidemia, is associated with reduced cardiac function in animals, but no studies showing an effect of acidemia on cardiac function in humans are reported. In the present study, we examined the effect of acidemia on cardiac function assessed with transpulmonary thermodilution technique with integrated pulse contour analysis (Pulse Contour Cardiac Output, PiCCO™) in a large cohort of critically ill patients.
METHODS
METHODS
This was a prospective multicenter observational cross-sectional study of 297 patients from 6 intensive care units in London, England selected from all patients admitted consecutively between May 2018 and March 2019. Measurements of lowest plasma pH and concurrent assessment of cardiac function were obtained.
FINDINGS
RESULTS
There was a significant difference between two pH categories (pH ≤ 7.28 vs. pH > 7.28) for the following variables of cardiac function: SVI (difference in means 32.7; 95% CI: 21 to 45 mL/m2;
INTERPRETATION
CONCLUSIONS
Acidemia is associated with impaired cardiac function in seriously ill patients hospitalized in the intensive care unit supporting the potential value of early diagnosis and improvement of arterial pH in these patients.
FUNDING
BACKGROUND
The study was partially supported by unrestricted funds from the UCLA School of Medicine.
Identifiants
pubmed: 34258569
doi: 10.1016/j.eclinm.2021.100956
pii: S2589-5370(21)00236-4
pmc: PMC8255172
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100956Informations de copyright
Crown Copyright © 2021 Published by Elsevier Ltd.
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