Characterization of the Functional Dynamics in the Neonatal Brain during REM and NREM Sleep States by means of Microstate Analysis.
EEG microstate analysis
Neonatal EEG
Neonatal brain dynamics
Sleep states
Journal
Brain topography
ISSN: 1573-6792
Titre abrégé: Brain Topogr
Pays: United States
ID NLM: 8903034
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
18
03
2021
accepted:
18
06
2021
pubmed:
15
7
2021
medline:
15
10
2021
entrez:
14
7
2021
Statut:
ppublish
Résumé
Neonates spend most of their life sleeping. During sleep, their brain experiences fast changes in its functional organization. Microstate analysis permits to capture the rapid dynamical changes occurring in the functional organization of the brain by representing the changing spatio-temporal features of the electroencephalogram (EEG) as a sequence of short-lasting scalp topographies-the microstates. In this study, we modeled the ongoing neonatal EEG into sequences of a limited number of microstates and investigated whether the extracted microstate features are altered in REM and NREM sleep (usually known as active and quiet sleep states-AS and QS-in the newborn) and depend on the EEG frequency band. 19-channel EEG recordings from 60 full-term healthy infants were analyzed using a modified version of the k-means clustering algorithm. The results show that ~ 70% of the variance in the datasets can be described using 7 dominant microstate templates. The mean duration and mean occurrence of the dominant microstates were significantly different in the two sleep states. Microstate syntax analysis demonstrated that the microstate sequences characterizing AS and QS had specific non-casual structures that differed in the two sleep states. Microstate analysis of the neonatal EEG in specific frequency bands showed a clear dependence of the explained variance on frequency. Overall, our findings demonstrate that (1) the spatio-temporal dynamics of the neonatal EEG can be described by non-casual sequences of a limited number of microstate templates; (2) the brain dynamics described by these microstate templates depends on frequency; (3) the features of the microstate sequences can well differentiate the physiological conditions characterizing AS and QS.
Identifiants
pubmed: 34258668
doi: 10.1007/s10548-021-00861-1
pii: 10.1007/s10548-021-00861-1
pmc: PMC8384814
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
555-567Informations de copyright
© 2021. The Author(s).
Références
Front Hum Neurosci. 2014 Dec 23;8:1030
pubmed: 25566040
Neuroimage. 2013 Mar;68:229-35
pubmed: 23246993
Neuroimage. 2020 Jul 15;215:116786
pubmed: 32276057
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3585-90
pubmed: 23401536
Hum Brain Mapp. 2017 Aug;38(8):4019-4033
pubmed: 28488308
Front Hum Neurosci. 2015 Apr 23;9:189
pubmed: 25954174
Semin Fetal Neonatal Med. 2006 Dec;11(6):471-8
pubmed: 17018268
J Clin Neurophysiol. 2010 Dec;27(6):458-64
pubmed: 21076326
Ann N Y Acad Sci. 2008;1129:330-4
pubmed: 18591492
Neuroimage. 2016 Jan 15;125:643-656
pubmed: 26285079
Neuroimage. 2017 Nov 15;162:353-361
pubmed: 28847493
Nat Commun. 2019 Jun 13;10(1):2619
pubmed: 31197175
Clin Neurophysiol. 2003 Jun;114(6):1053-68
pubmed: 12804674
PLoS Comput Biol. 2013;9(3):e1002985
pubmed: 23555220
Brain Struct Funct. 2020 Apr;225(3):1169-1183
pubmed: 32095901
Transl Psychiatry. 2021 Jan 18;11(1):60
pubmed: 33462192
Neuroimage. 2012 Apr 2;60(2):1562-73
pubmed: 22245347
Sci Rep. 2020 Oct 13;10(1):17069
pubmed: 33051536
Psychophysiology. 2000 Mar;37(2):163-78
pubmed: 10731767
Neurophysiol Clin. 2010 May;40(2):59-124
pubmed: 20510792
Semin Perinatol. 2011 Feb;35(1):34-43
pubmed: 21255705
Eur J Neurosci. 2005 Dec;22(11):2799-804
pubmed: 16324114
Electroencephalogr Clin Neurophysiol. 1980 Jun;48(6):609-21
pubmed: 6155251
Clin Neurophysiol. 2013 Jun;124(6):1106-14
pubmed: 23403263
Brain. 2015 Aug;138(Pt 8):2206-18
pubmed: 26001723
J Physiol. 2018 Dec;596(23):5687-5708
pubmed: 29691876
Clin Neurophysiol. 2011 Apr;122(4):696-702
pubmed: 21074493
Cereb Cortex. 2014 Oct;24(10):2657-68
pubmed: 23650289
Neurosci Biobehav Rev. 2015 Feb;49:105-13
pubmed: 25526823
Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15921-6
pubmed: 19717463
IEEE Trans Biomed Eng. 1995 Jul;42(7):658-65
pubmed: 7622149
J Neurosci. 2013 Apr 17;33(16):7079-90
pubmed: 23595765
J Neurosci Methods. 2019 Sep 1;325:108317
pubmed: 31302155
Neuroimage Clin. 2017 Apr 11;15:209-214
pubmed: 28529877
Schizophr Res Cogn. 2015 May 27;2(3):159-165
pubmed: 29379765
Cereb Cortex. 2019 Feb 1;29(2):814-826
pubmed: 30321291
Cereb Cortex. 2016 Dec;26(12):4540-4550
pubmed: 26405053
Neuroimage. 2017 Feb 1;146:533-543
pubmed: 27742598
Neuroimage. 2007 Feb 15;34(4):1600-11
pubmed: 17207640
Psychiatry Res. 2005 Feb 28;138(2):141-56
pubmed: 15766637
Neuroimage. 2002 May;16(1):41-8
pubmed: 11969316
Sci Rep. 2019 Sep 16;9(1):13319
pubmed: 31527749
J Neurosci. 2013 Oct 30;33(44):17363-72
pubmed: 24174669
Front Physiol. 2010 Sep 15;1:128
pubmed: 21423370
Electroencephalogr Clin Neurophysiol. 1987 Sep;67(3):271-88
pubmed: 2441961
J Affect Disord. 2020 Jul 1;272:326-334
pubmed: 32553374
Brain Topogr. 1999 Summer;11(4):257-63
pubmed: 10449257
J Clin Sleep Med. 2016 Mar;12(3):429-45
pubmed: 26951412
Neuroimage. 2010 Oct 1;52(4):1162-70
pubmed: 20188188
Neuroimage. 2018 Oct 15;180(Pt B):577-593
pubmed: 29196270
Neuroimage. 2012 Sep;62(3):2129-39
pubmed: 22658975
Brain Topogr. 2008 Jun;20(4):249-64
pubmed: 18347966
Neurogenesis (Austin). 2016 Oct 28;3(1):e1244439
pubmed: 27900344
Sci Rep. 2020 Feb 12;10(1):2469
pubmed: 32051420