Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics.
Methylisothiazolinone
cosmetics
safety
Journal
International journal of toxicology
ISSN: 1092-874X
Titre abrégé: Int J Toxicol
Pays: United States
ID NLM: 9708436
Informations de publication
Date de publication:
Historique:
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as a preservative in cosmetics. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessments of Methylisothiazolinone, and concluded that Methylisothiazolinone is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm (ie, 0.01%) and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment or similar methodology.
Identifiants
pubmed: 34259065
doi: 10.1177/10915818211015795
doi:
Substances chimiques
Cosmetics
0
Haptens
0
Preservatives, Pharmaceutical
0
Thiazoles
0
2-methyl-4-isothiazolin-3-one
229D0E1QFA
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM