Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics.
cosmetics
methylchloroisothiazolinone
methylisothiazolinone
safety
Journal
International journal of toxicology
ISSN: 1092-874X
Titre abrégé: Int J Toxicol
Pays: United States
ID NLM: 9708436
Informations de publication
Date de publication:
Historique:
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of the mixture Methylchloroisothiazolinone (MCI)/Methylisothiazolinone (MI), which functions as a preservative in cosmetic products. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessment of this mixture, and concluded that MCI/MI is safe in cosmetics when formulated to be nonsensitizing, based on the results of a quantitative risk assessment or similar methodology; however, at no point should concentrations exceed 7.5 ppm in leave-on products or 15 ppm in rinse-off products.
Identifiants
pubmed: 34259066
doi: 10.1177/10915818211016382
doi:
Substances chimiques
Cosmetics
0
Haptens
0
Preservatives, Pharmaceutical
0
Thiazoles
0
2-methyl-4-isothiazolin-3-one
229D0E1QFA
5-chloro-2-methyl-4-isothiazolin-3-one
DEL7T5QRPN
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM