Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
16
3
2022
Statut:
ppublish
Résumé
Autism spectrum disorder (ASD) is a major public health concern caused by complex genetic and environmental components. Mechanisms of gene-environment ( In this study, we aimed to identify a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 ( This study employed human iPSC-derived 3D brain organoids (BrainSpheres) carrying a heterozygote CRISPR/Cas9-introduced inactivating mutation in Expression of CHD8 protein was significantly lower in This study pioneered (
Sections du résumé
BACKGROUND
Autism spectrum disorder (ASD) is a major public health concern caused by complex genetic and environmental components. Mechanisms of gene-environment (
OBJECTIVES
In this study, we aimed to identify a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 (
METHODS
This study employed human iPSC-derived 3D brain organoids (BrainSpheres) carrying a heterozygote CRISPR/Cas9-introduced inactivating mutation in
RESULTS
Expression of CHD8 protein was significantly lower in
DISCUSSION
This study pioneered (
Identifiants
pubmed: 34259569
doi: 10.1289/EHP8580
pmc: PMC8278985
doi:
Substances chimiques
CHD8 protein, human
0
DNA-Binding Proteins
0
Transcription Factors
0
Chlorpyrifos
JCS58I644W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
77001Subventions
Organisme : NICHD NIH HHS
ID : P50 HD105352
Pays : United States
Commentaires et corrections
Type : CommentIn
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