Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders.
Neuromyelitis optica spectrum disorders
astrocytes
biomarker
disease activity
optical coherence tomography angiography
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
pubmed:
15
7
2021
medline:
5
4
2022
entrez:
14
7
2021
Statut:
ppublish
Résumé
Neuromyelitis optica spectrum disorders (NMOSD) are neuroinflammatory diseases of the central nervous system. Patients suffer from recurring relapses and it is unclear whether relapse-independent disease activity occurs and whether this is of clinical relevance. To detect disease-specific alterations of the retinal vasculature that reflect disease activity during NMOSD. Cross-sectional analysis of 16 patients with NMOSD, 21 patients with relapsing-remitting multiple sclerosis, and 21 healthy controls using retinal optical coherence tomography (OCT), optical coherence tomography angiography (OCT-A), measurement of glial fibrillary acidic protein (GFAP) serum levels, and assessment of visual acuity. Patients with NMOSD but not multiple sclerosis revealed lower foveal thickness (FT) ( Subclinical parafoveal retinal vessel loss might occur during NMOSD and might be linked to astrocyte damage and poor visual performance. OCT-A may be a tool to study subclinical disease activity during NMOSD.
Sections du résumé
BACKGROUND
Neuromyelitis optica spectrum disorders (NMOSD) are neuroinflammatory diseases of the central nervous system. Patients suffer from recurring relapses and it is unclear whether relapse-independent disease activity occurs and whether this is of clinical relevance.
OBJECTIVE
To detect disease-specific alterations of the retinal vasculature that reflect disease activity during NMOSD.
METHODS
Cross-sectional analysis of 16 patients with NMOSD, 21 patients with relapsing-remitting multiple sclerosis, and 21 healthy controls using retinal optical coherence tomography (OCT), optical coherence tomography angiography (OCT-A), measurement of glial fibrillary acidic protein (GFAP) serum levels, and assessment of visual acuity.
RESULTS
Patients with NMOSD but not multiple sclerosis revealed lower foveal thickness (FT) (
CONCLUSION
Subclinical parafoveal retinal vessel loss might occur during NMOSD and might be linked to astrocyte damage and poor visual performance. OCT-A may be a tool to study subclinical disease activity during NMOSD.
Identifiants
pubmed: 34259579
doi: 10.1177/13524585211028831
pmc: PMC8961243
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
522-531Références
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