Duck Tembusu virus induces stronger cellular responses than Japanese encephalitis virus in primary duck neurons and fibroblasts.
Japanese encephalitis virus
apoptosis
duck Tembusu virus
primary duck neuron
Journal
Microbiology and immunology
ISSN: 1348-0421
Titre abrégé: Microbiol Immunol
Pays: Australia
ID NLM: 7703966
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
20
05
2021
received:
17
11
2020
accepted:
12
07
2021
pubmed:
15
7
2021
medline:
16
11
2021
entrez:
14
7
2021
Statut:
ppublish
Résumé
Duck Tembusu virus (DTMUV) and Japanese encephalitis virus (JEV) are mosquito-borne flaviviruses. These two viruses infect ducks; however, they show different neurological outcomes. The mechanism of DTMUV- and JEV-induced neuronal death has not been well investigated. In the present study examined the differences in the mechanisms involved in virus-induced cell death and innate immune responses between the DTMUV KPS54A61 strain and the JEV JaGAr-01 strain using primary duck neurons (DN) and duck fibroblasts (CCL-141). DN and CCL-141 were permissive for the infection and replication of these two viruses, which up-regulated the expression of innate immunity genes. Both DTMUV and JEV induced cell death via a caspase-3-dependent manner; however, DTMUV triggered more cell death than did JEV in both CCL-141 and DN. These findings suggest that DTMUV infection causes apoptosis in duck neurons and fibroblasts more strongly than JEV. The levels of the mRNA expression of innate immunity-related genes after DTMUV infection were generally higher than the levels after JEV infection, suggesting that DTMUV-induced immune response in duck cells may exhibit toxic effects rather than protective effects.
Identifiants
pubmed: 34260084
doi: 10.1111/1348-0421.12933
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
481-491Informations de copyright
© 2021 The Societies and John Wiley & Sons Australia, Ltd.
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