A conserved epitope III on hepatitis C virus E2 protein has alternate conformations facilitating cell binding or virus neutralization.

Amino Acid Sequence Antibodies, Monoclonal / chemistry Conserved Sequence Epitopes / chemistry Hepacivirus / immunology Humans Molecular Docking Simulation Neutralization Tests Peptides / chemistry Protein Binding Protein Conformation Structural Homology, Protein Tetraspanin 28 / metabolism Viral Envelope Proteins / chemistry
E2 protein HCV conformation epitope III neutralization

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
13 07 2021
Historique:
entrez: 14 7 2021
pubmed: 15 7 2021
medline: 15 12 2021
Statut: ppublish

Résumé

Epitope III, a highly conserved amino acid motif of

Identifiants

DOI: 10.1073/pnas.2104242118 PMID: 34260404 PMC: PMC8285954
pubmed: 34260404
pii: 2104242118
doi: 10.1073/pnas.2104242118
pmc: PMC8285954
pii:
doi:

Substances chimiques

Antibodies, Monoclonal 0
Epitopes 0
Peptides 0
Tetraspanin 28 0
Viral Envelope Proteins 0
glycoprotein E2, Hepatitis C virus 157184-61-7

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

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Auteurs

Lu Deng (L)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.
ORCID: 0000-0002-3691-8820

Nancy Hernandez (N)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.
ORCID: 0000-0002-8307-4704

Lilin Zhong (L)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.

David D Holcomb (DD)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.

Hailing Yan (H)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.

Maria Luisa Virata (ML)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.
ORCID: 0000-0002-5559-5174

Sreya Tarafdar (S)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.
ORCID: 0000-0003-0339-2073

Yanqun Xu (Y)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.
ORCID: 0000-0003-1744-5586

Yong He (Y)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.

Evi Struble (E)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002.

Harvey J Alter (HJ)

Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD 20892 halter@dtm.cc.nih.gov pei.zhang@fda.hhs.gov.

Pei Zhang (P)

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002; halter@dtm.cc.nih.gov pei.zhang@fda.hhs.gov.
ORCID: 0000-0002-0572-2614

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Séquence conservée › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Hepacivirus › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Tests de neutralisation › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Phénomènes génétiques › Similitude structurale de protéines › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Tétraspanines › Antigène CD81 › A conserved epitope III on hepatitis C virus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › A conserved epitope III on hepatitis C virus...