SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2021
Historique:
received: 29 03 2021
accepted: 06 07 2021
pubmed: 15 7 2021
medline: 9 9 2021
entrez: 14 7 2021
Statut: ppublish

Résumé

An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape

Identifiants

pubmed: 34261126
doi: 10.1038/s41586-021-03807-6
pii: 10.1038/s41586-021-03807-6
pmc: PMC9282883
mid: NIHMS1819747
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antibodies, Viral 0
Broadly Neutralizing Antibodies 0
COVID-19 Vaccines 0
Epitopes, B-Lymphocyte 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

97-102

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM120553
Pays : United States
Organisme : NIAID NIH HHS
ID : DP1 AI158186
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124169
Pays : United States
Organisme : NIH HHS
ID : S10 OD023476
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM133894
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127893
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI083203
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-004949
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM121505
Pays : United States
Organisme : Wellcome Trust
ID : 209407/Z/17/Z
Pays : United Kingdom
Organisme : NIH HHS
ID : P30 GM124169-01
Pays : United States
Organisme : NIH HHS
ID : S10 OD028685
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM132386
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201700059C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141707
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136534
Pays : United States

Commentaires et corrections

Type : UpdateOf
Type : CommentIn

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Tyler N Starr (TN)

Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Nadine Czudnochowski (N)

Vir Biotechnology, San Francisco, CA, USA.

Zhuoming Liu (Z)

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.

Fabrizia Zatta (F)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Young-Jun Park (YJ)

Department of Biochemistry, University of Washington, Seattle, WA, USA.

Amin Addetia (A)

Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Dora Pinto (D)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Martina Beltramello (M)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Patrick Hernandez (P)

Vir Biotechnology, San Francisco, CA, USA.

Allison J Greaney (AJ)

Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Genome Sciences, University of Washington, Seattle, WA, USA.

Roberta Marzi (R)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

William G Glass (WG)

Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Ivy Zhang (I)

Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tri-Institutional PhD Program in Computational Biology and Medicine, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

Adam S Dingens (AS)

Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

John E Bowen (JE)

Department of Biochemistry, University of Washington, Seattle, WA, USA.

M Alejandra Tortorici (MA)

Department of Biochemistry, University of Washington, Seattle, WA, USA.

Alexandra C Walls (AC)

Department of Biochemistry, University of Washington, Seattle, WA, USA.

Jason A Wojcechowskyj (JA)

Vir Biotechnology, San Francisco, CA, USA.

Anna De Marco (A)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Laura E Rosen (LE)

Vir Biotechnology, San Francisco, CA, USA.

Jiayi Zhou (J)

Vir Biotechnology, San Francisco, CA, USA.

Martin Montiel-Ruiz (M)

Vir Biotechnology, San Francisco, CA, USA.

Hannah Kaiser (H)

Vir Biotechnology, San Francisco, CA, USA.

Josh R Dillen (JR)

Vir Biotechnology, San Francisco, CA, USA.

Heather Tucker (H)

Vir Biotechnology, San Francisco, CA, USA.

Jessica Bassi (J)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Chiara Silacci-Fregni (C)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Michael P Housley (MP)

Vir Biotechnology, San Francisco, CA, USA.

Julia di Iulio (J)

Vir Biotechnology, San Francisco, CA, USA.

Gloria Lombardo (G)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Maria Agostini (M)

Vir Biotechnology, San Francisco, CA, USA.

Nicole Sprugasci (N)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Katja Culap (K)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Stefano Jaconi (S)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Marcel Meury (M)

Vir Biotechnology, San Francisco, CA, USA.

Exequiel Dellota (E)

Vir Biotechnology, San Francisco, CA, USA.

Rana Abdelnabi (R)

Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium.

Shi-Yan Caroline Foo (SC)

Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium.

Elisabetta Cameroni (E)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Spencer Stumpf (S)

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.

Tristan I Croll (TI)

Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Cambridge, UK.

Jay C Nix (JC)

Molecular Biology Consortium, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Colin Havenar-Daughton (C)

Vir Biotechnology, San Francisco, CA, USA.

Luca Piccoli (L)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Fabio Benigni (F)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Johan Neyts (J)

Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium.

Amalio Telenti (A)

Vir Biotechnology, San Francisco, CA, USA.

Florian A Lempp (FA)

Vir Biotechnology, San Francisco, CA, USA.

Matteo S Pizzuto (MS)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

John D Chodera (JD)

Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Christy M Hebner (CM)

Vir Biotechnology, San Francisco, CA, USA.

Herbert W Virgin (HW)

Vir Biotechnology, San Francisco, CA, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Sean P J Whelan (SPJ)

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.

David Veesler (D)

Department of Biochemistry, University of Washington, Seattle, WA, USA.

Davide Corti (D)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland. dcorti@vir.bio.

Jesse D Bloom (JD)

Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. jbloom@fredhutch.org.
Department of Genome Sciences, University of Washington, Seattle, WA, USA. jbloom@fredhutch.org.
Howard Hughes Medical Institute, Seattle, WA, USA. jbloom@fredhutch.org.

Gyorgy Snell (G)

Vir Biotechnology, San Francisco, CA, USA. gsnell@vir.bio.

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Classifications MeSH