G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.
Animals
Conditioning, Operant
/ physiology
Emotions
/ physiology
Excitatory Postsynaptic Potentials
/ physiology
G Protein-Coupled Inwardly-Rectifying Potassium Channels
/ physiology
Hippocampus
/ physiology
Learning
/ physiology
Long-Term Potentiation
/ physiology
Male
Mice
Mice, Inbred C57BL
Motor Activity
/ physiology
Nerve Tissue Proteins
/ physiology
Neuronal Plasticity
/ physiology
Psychomotor Performance
/ physiology
Kir3/GirK
LTP/LTD
ex vivo
hippocampus
in vivo
metaplasticity
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
18 08 2021
18 08 2021
Historique:
received:
05
11
2020
revised:
11
05
2021
accepted:
04
06
2021
pubmed:
16
7
2021
medline:
30
11
2021
entrez:
15
7
2021
Statut:
ppublish
Résumé
The G-protein-gated inwardly rectifying potassium (Kir3/GIRK) channel is the effector of many G-protein-coupled receptors (GPCRs). Its dysfunction has been linked to the pathophysiology of Down syndrome, Alzheimer's and Parkinson's diseases, psychiatric disorders, epilepsy, drug addiction, or alcoholism. In the hippocampus, GIRK channels decrease excitability of the cells and contribute to resting membrane potential and inhibitory neurotransmission. Here, to elucidate the role of GIRK channels activity in the maintenance of hippocampal-dependent cognitive functions, their involvement in controlling neuronal excitability at different levels of complexity was examined in C57BL/6 male mice. For that purpose, GIRK activity in the dorsal hippocampus CA3-CA1 synapse was pharmacologically modulated by two drugs: ML297, a GIRK channel opener, and Tertiapin-Q (TQ), a GIRK channel blocker.
Identifiants
pubmed: 34261700
pii: JNEUROSCI.2849-20.2021
doi: 10.1523/JNEUROSCI.2849-20.2021
pmc: PMC8372024
doi:
Substances chimiques
G Protein-Coupled Inwardly-Rectifying Potassium Channels
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7086-7102Informations de copyright
Copyright © 2021 the authors.
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