TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study.

Journal

NPJ precision oncology
ISSN: 2397-768X
Titre abrégé: NPJ Precis Oncol
Pays: England
ID NLM: 101708166

Informations de publication

Date de publication:
14 Jul 2021
Historique:
received: 08 10 2020
accepted: 16 04 2021
entrez: 15 7 2021
pubmed: 16 7 2021
medline: 16 7 2021
Statut: epublish

Résumé

In children with cancer, the heterogeneity in ototoxicity occurrence after similar treatment suggests a role for genetic susceptibility. Using a genome-wide association study (GWAS) approach, we identified a genetic variant in TCERG1L (rs893507) to be associated with hearing loss in 390 non-cranial irradiated, cisplatin-treated children with cancer. These results were replicated in two independent, similarly treated cohorts (n = 192 and 188, respectively) (combined cohort: P = 5.3 × 10

Identifiants

DOI: 10.1038/s41698-021-00178-z PMID: 34262104 PMC: PMC8280110
pubmed: 34262104
doi: 10.1038/s41698-021-00178-z
pii: 10.1038/s41698-021-00178-z
pmc: PMC8280110
doi:

Types de publication

Journal Article

Langues

eng

Pagination

64

Investigateurs

A C H de Vries (ACH)
M van Grotel (M)
E van Dulmen-den Broeder (E)
A L F van der Kooi (ALF)
L C M Kremer (LCM)
H J H van der Pal (HJH)
G Calaminus (G)
A E Hoetink (AE)
M M van den Heuvel-Eibrink (MM)

Informations de copyright

© 2021. The Author(s).

Références

J Clin Oncol. 2016 Apr 10;34(11):1248-55
pubmed: 26811531
Database (Oxford). 2015 Jul 24;2015:bav071
pubmed: 26209310
Eur J Cancer. 2018 Nov;103:238-248
pubmed: 30286417
Mol Med Rep. 2014 Feb;9(2):725-9
pubmed: 24317008
Nat Commun. 2017 Nov 28;8(1):1826
pubmed: 29184056
Nat Commun. 2014 Jun 13;5:3934
pubmed: 25653097
BMC Res Notes. 2014 Dec 11;7:901
pubmed: 25495213
PLoS Genet. 2006 Dec;2(12):e190
pubmed: 17194218
Stem Cell Reports. 2013 Dec 26;2(1):36-43
pubmed: 24511466
J Clin Oncol. 2005 Dec 1;23(34):8588-96
pubmed: 16314621
Pediatr Hematol Oncol. 2017 Mar;34(2):120-129
pubmed: 28590156
Tumour Biol. 2012 Apr;33(2):363-72
pubmed: 22238052
BMC Med Genet. 2014 Feb 06;15:18
pubmed: 24499112
J Neurosci. 2015 Apr 22;35(16):6366-80
pubmed: 25904789
J Clin Oncol. 2014 Feb 20;32(6):527-34
pubmed: 24419114
Nat Genet. 2012 Jul 22;44(8):955-9
pubmed: 22820512
Pharmacogenomics J. 2009 Feb;9(1):23-33
pubmed: 18301416
Sci Rep. 2019 Oct 23;9(1):15192
pubmed: 31645637
HNO. 2007 Apr;55(4):299-306
pubmed: 16437215
Pharmacogenomics. 2011 Jul;12(7):1039-50
pubmed: 21787192
Eur J Cancer. 2004 Nov;40(16):2445-51
pubmed: 15519518
Nat Commun. 2019 Jan 18;10(1):309
pubmed: 30659176
Cancer Treat Rev. 2010 Jun;36(4):277-85
pubmed: 20231056
Blood. 2013 Jun 27;121(26):5145-53
pubmed: 23652803
N Engl J Med. 2006 Oct 12;355(15):1572-82
pubmed: 17035650
JMIR Res Protoc. 2019 Mar 19;8(3):e11868
pubmed: 30888333
Front Cell Neurosci. 2017 Oct 27;11:338
pubmed: 29163050
Lancet Oncol. 2019 Jan;20(1):e29-e41
pubmed: 30614474
Pharmacoepidemiol Drug Saf. 2009 Aug;18(8):713-21
pubmed: 19507171
Int J Mol Med. 2013 May;31(5):1255-61
pubmed: 23546389
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161

Auteurs

A J M Meijer (AJM)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. a.j.m.meijer-16@prinsesmaximacentrum.nl.
ORCID: 0000-0003-1631-0006

F A Diepstraten (FA)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
ORCID: 0000-0002-2507-1820

T Langer (T)

Department of Pediatric Oncology and Hematology, University Hospital for Children and Adolescents, Lübeck, Germany.

L Broer (L)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

I K Domingo (IK)

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.

E Clemens (E)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.

A G Uitterlinden (AG)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0002-7276-3387

A C H de Vries (ACH)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.

M van Grotel (M)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

W P Vermeij (WP)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.
ORCID: 0000-0002-9690-1385

R A Ozinga (RA)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

H Binder (H)

German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

J Byrne (J)

Boyne Research Institute, Drogheda, Ireland.

E van Dulmen-den Broeder (E)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
VU Medical Center, Amsterdam, The Netherlands.

M L Garrè (ML)

Department of Neurooncology, IRCCS Istituto Giannina Gaslini, Genova, Italy.

D Grabow (D)

German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

P Kaatsch (P)

German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

M Kaiser (M)

German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

L Kenborg (L)

Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.

J F Winther (JF)

Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health, Aarhus University and University Hospital, Aarhus, Denmark.

C Rechnitzer (C)

Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

H Hasle (H)

Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
ORCID: 0000-0003-3976-9231

T Kepak (T)

University Hospital Brno, Brno, Czech Republic.
International Clinical Research Center (FNUSA-ICRC), Brno, Czech Republic.
ORCID: 0000-0002-1449-5273

K Kepakova (K)

University Hospital Brno, Brno, Czech Republic.
International Clinical Research Center (FNUSA-ICRC), Brno, Czech Republic.

W J E Tissing (WJE)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Pediatric Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

A L F van der Kooi (ALF)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Obstetrics and Gynecology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
ORCID: 0000-0003-0497-3814

L C M Kremer (LCM)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Pediatric Oncology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.

J Kruseova (J)

Department of Children Hemato-Oncology, Motol University Hospital Prague, Prague, Czech Republic.

S M F Pluijm (SMF)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

C E Kuehni (CE)

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Pediatric Hematology and Oncology, University Children's Hospital Bern, University of Bern, Bern, Switzerland.
ORCID: 0000-0001-8957-2002

H J H van der Pal (HJH)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Pediatric Oncology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.

R Parfitt (R)

Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.

C Spix (C)

German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

A Tillmanns (A)

Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.

D Deuster (D)

Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.

P Matulat (P)

Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.

G Calaminus (G)

Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.

A E Hoetink (AE)

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Utrecht, Utrecht, The Netherlands.
ORCID: 0000-0002-7417-5546

S Elsner (S)

Institute of Social Medicine and Epidemiology, University of Lübeck, Lübeck, Germany.

J Gebauer (J)

Department of Internal Medicine, University Hospital of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

R Haupt (R)

Epidemiology and Biostatistics Unit and DOPO Clinic, IRCCS Istituto Giannina Gaslini, Genova, Italy.

H Lackner (H)

Department of Pediatric and Adolescent Medicine, Medical University of Graz, Graz, Austria.

C Blattmann (C)

Department of Pediatric Oncology/Hematology/Immunology, Stuttgart Cancer Center, Olgahospital, Stuttgart, Germany.

S J C M M Neggers (SJCMM)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

S R Rassekh (SR)

BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

G E B Wright (GEB)

BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

B Brooks (B)

Audiology and Speech Pathology Department, BC Children's Hospital, Vancouver, BC, Canada.

A P Nagtegaal (AP)

Departement of Otorhinolaryngology, Erasmus Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0001-8128-7178

B I Drögemöller (BI)

BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Faculty of Pharmaceutical Sciences, University of British Columbia, British Columbia, Canada.
ORCID: 0000-0002-3348-5855

C J D Ross (CJD)

BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Faculty of Pharmaceutical Sciences, University of British Columbia, British Columbia, Canada.
ORCID: 0000-0003-1476-7037

A P Bhavsar (AP)

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada.

A G Am Zehnhoff-Dinnesen (AG)

Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.

B C Carleton (BC)

BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Faculty of Pharmaceutical Sciences, University of British Columbia, British Columbia, Canada.
ORCID: 0000-0002-4485-4054

O Zolk (O)

Institute of Clinical Pharmacology, Brandenburg Medical School, Rüdersdorf, Germany.
ORCID: 0000-0002-8220-3834

M M van den Heuvel-Eibrink (MM)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
ORCID: 0000-0002-7760-879X

Classifications MeSH