Retro mode illumination for detecting and quantifying the area of geographic atrophy in non-neovascular age-related macular degeneration.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
28
12
2020
accepted:
23
06
2021
revised:
11
06
2021
pubmed:
16
7
2021
medline:
27
7
2022
entrez:
15
7
2021
Statut:
ppublish
Résumé
To evaluate the ability of retro mode illumination imaging for quantifying atrophy compared to confocal color fundus photography (c-CFP), green light fundus autofluorescence (G-FAF), blue light fundus autofluorescence (B-FAF) using the scanning laser ophthalmoscope (SLO) Mirante device by Nidek (Nidek Co., Ltd, Gamogori, Japan). Eyes with clinical evidence of geographic atrophy (GA) associated with non-neovascular age-related macular degeneration, evaluated at the Doheny Eye Centers-UCLA and Hospital Sacco Milan, were included in this prospective, cross-sectional study. All eyes were imaged with multiple retinal imaging modalities using the SLO Nidek Mirante device: c-CFP, G-FAF, B-FAF, retro mode illumination deviated-right (RMDR), and deviated-left (RMDL). Masked graders measured the GA lesion on each modality and inter-modality and inter-grader repeatability were assessed. The mean (SD) area of GA measured 9.76 (3.82) mm Retro mode imaging demonstrated good agreement for measuring GA compared to other imaging modalities, with a high level of repeatability. Given that retro mode imaging uses infrared light and is comfortable, it may prove to be a useful tool for the assessment of GA in the clinic.
Identifiants
pubmed: 34262164
doi: 10.1038/s41433-021-01670-3
pii: 10.1038/s41433-021-01670-3
pmc: PMC9307798
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1560-1566Informations de copyright
© 2021. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
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