Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K.
COVID-19
SARS-CoV-2
lineage
spike
variant of interest
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
04
2021
accepted:
31
05
2021
entrez:
15
7
2021
pubmed:
16
7
2021
medline:
16
7
2021
Statut:
epublish
Résumé
COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage.
Identifiants
pubmed: 34262921
doi: 10.3389/fmed.2021.697605
pmc: PMC8273171
doi:
Types de publication
Journal Article
Langues
eng
Pagination
697605Subventions
Organisme : Bill & Melinda Gates Foundation
ID : INV-003070
Pays : United States
Informations de copyright
Copyright © 2021 Laiton-Donato, Usme-Ciro, Franco-Muñoz, Álvarez-Díaz, Ruiz-Moreno, Reales-González, Prada, Corchuelo, Herrera-Sepúlveda, Naizaque, Santamaría, Wiesner, Walteros, Ospina Martínez and Mercado-Reyes.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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