Cefiderocol Activity Against Clinical
AmpC
antimicrobial resistance
ceftazidime-avibactam
omega loop
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
11
03
2021
accepted:
10
06
2021
entrez:
15
7
2021
pubmed:
16
7
2021
medline:
16
7
2021
Statut:
epublish
Résumé
Mutations in the AmpC-AmpR region are associated with treatment-emergent ceftolozane-tazobactam (TOL-TAZ) and ceftazidime-avibactam (CAZ-AVI) resistance. We sought to determine if these mutations impact susceptibility to the novel cephalosporin-siderophore compound cefiderocol. Thirty-two paired isolates from 16 patients with index Analyzing the 16 pairs of Our findings suggest that alterations in the target binding sites of
Sections du résumé
BACKGROUND
BACKGROUND
Mutations in the AmpC-AmpR region are associated with treatment-emergent ceftolozane-tazobactam (TOL-TAZ) and ceftazidime-avibactam (CAZ-AVI) resistance. We sought to determine if these mutations impact susceptibility to the novel cephalosporin-siderophore compound cefiderocol.
METHODS
METHODS
Thirty-two paired isolates from 16 patients with index
RESULTS
RESULTS
Analyzing the 16 pairs of
CONCLUSIONS
CONCLUSIONS
Our findings suggest that alterations in the target binding sites of
Identifiants
pubmed: 34262990
doi: 10.1093/ofid/ofab311
pii: ofab311
pmc: PMC8275882
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofab311Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
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