Factors associated with changes in volumetric bone mineral density and cortical area in men with ankylosing spondylitis: a 5-year prospective study using HRpQCT.
Bone mineral density
DXA
high-resolution peripheral quantitative computed tomography
other diseases related to bone (ankylosing spondylitis)
radiology
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
ISSN: 1433-2965
Titre abrégé: Osteoporos Int
Pays: England
ID NLM: 9100105
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
19
10
2020
accepted:
24
06
2021
pubmed:
16
7
2021
medline:
18
1
2022
entrez:
15
7
2021
Statut:
ppublish
Résumé
Patients with ankylosing spondylitis (AS) have impaired volumetric bone mineral density (vBMD) assessed with high-resolution peripheral computed tomography (HRpQCT). This first longitudinal HRpQCT study in AS shows that cortical and trabecular vBMD decreased at tibia and that signs of inflammation were associated with cortical bone loss at tibia and radius. Patients with ankylosing spondylitis (AS) have reduced volumetric bone mineral density (vBMD) in the peripheral skeleton assessed with high-resolution peripheral quantitative computed tomography (HRpQCT). The aims were to investigate longitudinal changes in vBMD, cortical area, and microarchitecture and to assess factors associated with changes in vBMD and cortical area in men with AS. HRpQCT of radius and tibia was performed in 54 men with AS at baseline and after 5 years. Univariate and multivariable linear regression analyses were used. At tibia, there were significant decreases exceeding least significant changes (LSC) in cortical and trabecular vBMD, mean (SD) percent change -1.0 (1.9) and -2.7 (5.0) respectively (p<0.001). In multivariable regression analyses, increase in disease activity measured by ASDAS_CRP from baseline to follow-up was associated with decreases in cortical vBMD (β -0.86, 95% CI -1.31 to -0.41) and cortical area (β -1.66, 95% CI -3.21 to -0.10) at tibia. At radius, no changes exceeded LSC. Nonetheless, increase in ASDAS_CRP was associated with decreases in cortical vBMD, and high time-averaged ESR was associated with decreases in cortical area. Treatment with TNF inhibitor ≥ 4 years during follow-up was associated with increases in cortical vBMD and cortical area at tibia, whereas exposure to bisphosphonates was associated with increases in cortical measurements at radius. No disease-related variables or treatments were associated with changes in trabecular vBMD. The findings in this first longitudinal HRpQCT study in patients with AS strengthen the importance of controlling disease activity to maintain bone density in the peripheral skeleton.
Identifiants
pubmed: 34263348
doi: 10.1007/s00198-021-06049-4
pii: 10.1007/s00198-021-06049-4
pmc: PMC8758642
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-216Subventions
Organisme : Västra Götalandsregionen
ID : VGFOUREG-383071
Organisme : Västra Götalandsregionen
ID : VGFOUREG-564511, VGFOUREG-754661
Organisme : Vetenskapsrådet
ID : 2016-02035
Organisme : Vetenskapsrådet
ID : 2017-02229
Organisme : The Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement
ID : ALFGBG-141111, ALFGBG-430851, , ALFVLL-640251
Organisme : The Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement
ID : ALFGBG-716051
Organisme : Göteborgs Läkaresällskap
ID : GLS-880811, GLS-498111, GLS-406801
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
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