Bioluminescence Imaging of Urokinase-Type Plasminogen Activator Activity

Humans Neoplasms / diagnostic imaging Receptors, Urokinase Plasminogen Activator Urokinase-Type Plasminogen Activator

Journal

Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536

Informations de publication

Date de publication:
27 07 2021
Historique:
pubmed: 16 7 2021
medline: 10 8 2021
entrez: 15 7 2021
Statut: ppublish

Résumé

Urokinase-type plasminogen activator (uPA) is a cell-secreted serine protease and plays a significant role in numerous biological processes. Overexpression of uPA has been proved to be relevant to some malignant tumors as well as poor prognosis. However, bioluminescence (BL) probes for selectively sensing uPA activity have not been reported up to now. Herein, we designed a BL probe, GGR-AmLuc, to detect uPA

Identifiants

DOI: 10.1021/acs.analchem.1c02499 PMID: 34264075
pubmed: 34264075
doi: 10.1021/acs.analchem.1c02499
doi:

Substances chimiques

Receptors, Urokinase Plasminogen Activator 0
Urokinase-Type Plasminogen Activator EC 3.4.21.73

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9970-9973

Auteurs

Yinglu Chen (Y)

Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.

Chengfan Wu (C)

Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.

Chenchen Wang (C)

Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.

Tong Zhang (T)

School of Life Sciences, University of Science and Technology of China, 443 Huangshan Road, Hefei, Anhui 230027, China.

Yue Hua (Y)

Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing, Jiangsu 210009, China.

Yang Shen (Y)

Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing, Jiangsu 210009, China.

Gaolin Liang (G)

Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, Jiangsu 210096, China.
ORCID: 0000-0002-6159-9999

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bioluminescence Imaging of Urokinase-Type...
questionsmedicales.fr › Tumeurs › Bioluminescence Imaging of Urokinase-Type...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à l'activateur du plasminogène de type urokinase › Bioluminescence Imaging of Urokinase-Type...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Activateurs du plasminogène › Activateur du plasminogène de type urokinase › Bioluminescence Imaging of Urokinase-Type...