Telomeres: New players in immune-mediated inflammatory diseases?
Dynamics
Immune-mediated inflammatory diseases
Telomere
Journal
Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
25
05
2021
revised:
02
07
2021
accepted:
05
07
2021
pubmed:
16
7
2021
medline:
22
2
2022
entrez:
15
7
2021
Statut:
ppublish
Résumé
Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that preserve the integrity and stability of the genome. Telomere dysfunctions due to short telomeres or altered telomere structures can ultimately lead to replicative cellular senescence and chromosomal instability, both mechanisms being hallmarks of ageing. Chronic inflammation, oxidative stress and finally telomere length (TL) dynamics have been shown to be involved in various age-related non-communicable diseases (NCDs). Immune-mediated inflammatory diseases (IMIDs), including affections such as inflammatory bowel disease, psoriasis, rheumatoid arthritis, spondyloarthritis and uveitis belong to this group of age-related NCDs. Although in recent years, we have witnessed the emergence of studies in the literature linking these IMIDs to TL dynamics, the causality between these diseases and telomere attrition is still unclear and controversial. In this review, we provide an overview of available studies on telomere dynamics and discuss the utility of TL measurements in immune-mediated inflammatory diseases.
Identifiants
pubmed: 34265700
pii: S0896-8411(21)00107-4
doi: 10.1016/j.jaut.2021.102699
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102699Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.