The Gut Microbiota of Critically Ill Patients With COVID-19.
COVID-19
SARS-CoV-2
bloodstream infection
gut microbiota
intensive care unit
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
02
2021
accepted:
03
06
2021
entrez:
16
7
2021
pubmed:
17
7
2021
medline:
21
7
2021
Statut:
epublish
Résumé
The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being paid to the possible role of the gut microbiota (GM). Fecal samples from 69 COVID-19 patients from three different hospitals of Bologna (Italy) were analyzed by 16S rRNA gene-based sequencing. The GM profile was compared with the publicly available one of healthy age- and gender-matched Italians, as well as with that of other critically ill non-COVID-19 patients. The GM of COVID-19 patients appeared severely dysbiotic, with reduced diversity, loss of health-associated microorganisms and enrichment of potential pathogens, particularly
Identifiants
pubmed: 34268136
doi: 10.3389/fcimb.2021.670424
pmc: PMC8276076
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
670424Informations de copyright
Copyright © 2021 Gaibani, D’Amico, Bartoletti, Lombardo, Rampelli, Fornaro, Coladonato, Siniscalchi, Re, Viale, Brigidi, Turroni and Giannella.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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