TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans.

Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Carrier Proteins / genetics Cullin Proteins / genetics DNA Replication DNA-Directed DNA Polymerase / metabolism Multienzyme Complexes / metabolism Synthetic Lethal Mutations
CDC-48 CMG helicase CUL-2LRR-1 DNA replication termination TIMELESS-TIPIN UBXN-3

Journal

The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664

Informations de publication

Date de publication:
01 09 2021
Historique:
revised: 10 06 2021
received: 17 02 2021
accepted: 11 06 2021
pubmed: 17 7 2021
medline: 30 11 2021
entrez: 16 7 2021
Statut: ppublish

Résumé

The eukaryotic replisome is rapidly disassembled during DNA replication termination. In metazoa, the cullin-RING ubiquitin ligase CUL-2

Identifiants

DOI: 10.15252/embj.2021108053 PMID: 34269473 PMC: PMC8408604
pubmed: 34269473
doi: 10.15252/embj.2021108053
pmc: PMC8408604
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
Carrier Proteins 0
Cullin Proteins 0
Multienzyme Complexes 0
TIM-1 protein, C elegans 0
UBXN-3 protein, C elegans 0
DNA synthesome EC 2.7.7.-
DNA-Directed DNA Polymerase EC 2.7.7.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e108053

Subventions

Organisme : Cancer Research UK
ID : 24558
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12016/13
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204678/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C578/A24558
Pays : United Kingdom

Informations de copyright

© 2021 The Authors. Published under the terms of the CC BY 4.0 license.

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Auteurs

Yisui Xia (Y)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
ORCID: 0000-0002-5576-2147

Ryo Fujisawa (R)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
ORCID: 0000-0003-1985-1668

Tom D Deegan (TD)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
ORCID: 0000-0001-9639-7636

Remi Sonneville (R)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
ORCID: 0000-0002-2149-2652

Karim P M Labib (KPM)

The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
ORCID: 0000-0001-8861-379X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › TIMELESS-TIPIN and UBXN-3 promote replisome...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › TIMELESS-TIPIN and UBXN-3 promote replisome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › TIMELESS-TIPIN and UBXN-3 promote replisome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › TIMELESS-TIPIN and UBXN-3 promote replisome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Cullines › TIMELESS-TIPIN and UBXN-3 promote replisome...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › TIMELESS-TIPIN and UBXN-3 promote replisome...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › DNA nucleotidyltransferases › DNA-directed DNA polymerase › TIMELESS-TIPIN and UBXN-3 promote replisome...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › TIMELESS-TIPIN and UBXN-3 promote replisome...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutations synthétiques létales › TIMELESS-TIPIN and UBXN-3 promote replisome...