Long-Term Safety of Rituximab (Risks of Viral and Opportunistic Infections).
Antirheumatic Agents
/ therapeutic use
Antiviral Agents
/ therapeutic use
COVID-19
/ epidemiology
Hepatitis B
/ diagnosis
Humans
Immunocompromised Host
Latent Infection
/ diagnosis
Mass Screening
Opportunistic Infections
/ epidemiology
Risk
Rituximab
/ therapeutic use
SARS-CoV-2
Virus Diseases
/ epidemiology
COVID-19
Hepatitis B
Infection
Rituximab
SARS-CoV-2
Journal
Current rheumatology reports
ISSN: 1534-6307
Titre abrégé: Curr Rheumatol Rep
Pays: United States
ID NLM: 100888970
Informations de publication
Date de publication:
16 07 2021
16 07 2021
Historique:
accepted:
25
05
2021
entrez:
16
7
2021
pubmed:
17
7
2021
medline:
24
7
2021
Statut:
epublish
Résumé
We reviewed the current data on infections associated with rituximab use published over the last 5 years. New literature was available on rates of serious infections, Hepatitis B reactivation and screening, and infection with Severe Acute Respiratory Syndrome Coronavirus 2. Rates of infection varied by study and population, however, higher risk of infection in patients with underlying rheumatologic diseases was seen in those who required a therapy switch, had a smoking history, and those undergoing retreatment who had a serious infection with their first course of therapy. With regards to HBV, the proportion of patients screened continues to be inadequate. Despite the upfront cost, HBV screening and prophylaxis were found to be cost effective. There is still limited data regarding COVID-19 severity in the setting of rituximab, however, rituximab, especially in combination with steroids, may lead to more severe disease and higher mortality.
Identifiants
pubmed: 34269903
doi: 10.1007/s11926-021-01037-3
pii: 10.1007/s11926-021-01037-3
pmc: PMC8284038
doi:
Substances chimiques
Antirheumatic Agents
0
Antiviral Agents
0
Rituximab
4F4X42SYQ6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
74Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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