Determination of Biological Age: Geriatric Assessment vs Biological Biomarkers.

Aged Aging / genetics Biomarkers / metabolism Epigenesis, Genetic / genetics Frail Elderly Frailty / diagnosis Gene Expression Profiling / methods Geriatric Assessment / methods Humans Proteomics / methods Telomere / genetics
Aging Biomarkers Comprehensive geriatric assessment Epigenetics Frailty Frailty index Oncogeriatrics

Journal

Current oncology reports
ISSN: 1534-6269
Titre abrégé: Curr Oncol Rep
Pays: United States
ID NLM: 100888967

Informations de publication

Date de publication:
16 07 2021
Historique:
accepted: 20 05 2021
entrez: 16 7 2021
pubmed: 17 7 2021
medline: 24 2 2022
Statut: epublish

Résumé

Biological age is the concept of using biophysiological measures to more accurately determine an individual's age-related risk of adverse outcomes. Grading of the degree of frailty and measuring biomarkers are distinct methods of measuring biological age. This review compares these strategies for estimating biological age for clinical purposes. The degree of frailty predicts susceptibility to adverse outcomes independently of chronological age. The utility of this approach has been demonstrated across a range of clinical contexts. Biomarkers from various levels of the biological aging process are improving in accuracy, with the potential to identify aberrant aging trajectories before the onset of clinically manifest frailty. Grading of frailty is a demonstrably, clinically, and research-relevant proxy estimate of biological age. Emerging biomarkers can supplement this approach by identifying accelerated aging before it is clinically apparent. Some biomarkers may even offer a means by which interventions to reduce the rate of aging can be developed.

Identifiants

DOI: 10.1007/s11912-021-01097-9 PMID: 34269912 PMC: PMC8284182
pubmed: 34269912
doi: 10.1007/s11912-021-01097-9
pii: 10.1007/s11912-021-01097-9
pmc: PMC8284182
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

104

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Lucas W M Diebel (LWM)

Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Nova Scotia Health Authority, Halifax, Canada.
Centre for Health Care of the Elderly, Veterans' Memorial Building, 4121-5955 Veterans' Memorial Lane, Halifax, Nova Scotia, B3H 2E9, Canada.

Kenneth Rockwood (K)

Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Nova Scotia Health Authority, Halifax, Canada. Kenneth.Rockwood@nshealth.ca.
Centre for Health Care of the Elderly, Veterans' Memorial Building, 4121-5955 Veterans' Memorial Lane, Halifax, Nova Scotia, B3H 2E9, Canada. Kenneth.Rockwood@nshealth.ca.
Department of Medicine, Divisions of Geriatric Medicine & Neurology, Dalhousie University, Nova Scotia Health Authority, Halifax, Canada. Kenneth.Rockwood@nshealth.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Personne âgée fragile › Determination of Biological Age: Geriatric...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Évaluation gériatrique › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Determination of Biological Age: Geriatric...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Determination of Biological Age: Geriatric...