Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations.
carbohydrates
dyslipidemia
epidemiology
genetics
nutrition
sugars
triglyceride
Journal
Circulation. Genomic and precision medicine
ISSN: 2574-8300
Titre abrégé: Circ Genom Precis Med
Pays: United States
ID NLM: 101714113
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
17
7
2021
medline:
12
2
2022
entrez:
16
7
2021
Statut:
ppublish
Résumé
ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele; Our results identified genetic variants in the
Sections du résumé
BACKGROUND
ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the
METHODS
Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near
RESULTS
In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele;
CONCLUSIONS
Our results identified genetic variants in the
Identifiants
pubmed: 34270325
doi: 10.1161/CIRCGEN.120.003288
pmc: PMC8373451
mid: NIHMS1724674
doi:
Substances chimiques
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Cholesterol, HDL
0
MLXIPL protein, human
0
Triglycerides
0
Banques de données
ClinicalTrials.gov
['NCT00000479', 'NCT00005487', 'NCT00005121', 'NCT00005133']
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e003288Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : R15 HG006915
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100425
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 16CSA28590003-HERMAN
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL069772
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009001
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00006/3
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK121710
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL151855
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA182913
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK078616
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL112845
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149683
Pays : United States
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