Precision Medicine and Heterogeneity of Treatment Effect in Therapies for ARDS.

Biological Variation, Population Genetic Heterogeneity Humans Precision Medicine / methods Respiratory Distress Syndrome / genetics Treatment Outcome
ARDS acute respiratory failure heterogeneity of treatment effect

Journal

Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335

Informations de publication

Date de publication:
11 2021
Historique:
received: 08 03 2021
revised: 28 06 2021
accepted: 05 07 2021
pubmed: 17 7 2021
medline: 12 1 2022
entrez: 16 7 2021
Statut: ppublish

Résumé

ARDS is a clinically heterogeneous syndrome, rather than a distinct disease. This heterogeneity at least partially explains the difficulty in studying treatments for these patients and contributes to the numerous trials of therapies for the syndrome that have not shown benefit. Recent studies have identified different subphenotypes within the heterogeneous patient population. These different subphenotypes likely have variable clinical responses to specific therapies, a concept known as heterogeneity of treatment effect. Recognizing different subphenotypes and heterogeneity of treatment effect has important implications for the clinical management of patients with ARDS. This review presents studies that have identified different subphenotypes and discusses how they can modify the effects of therapies evaluated in trials that are commonly considered to have shown no overall benefit in patients with ARDS.

Identifiants

DOI: 10.1016/j.chest.2021.07.009 PMID: 34270967 PMC: PMC8277554
pubmed: 34270967
pii: S0012-3692(21)01327-1
doi: 10.1016/j.chest.2021.07.009
pmc: PMC8277554
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1729-1738

Informations de copyright

Copyright © 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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Auteurs

Yasin A Khan (YA)

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Eddy Fan (E)

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Toronto General Hospital Research Institute, Toronto, ON, Canada; Division of Respirology, Department of Medicine, University Health Network, Toronto, ON, Canada.

Niall D Ferguson (ND)

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Toronto General Hospital Research Institute, Toronto, ON, Canada; Division of Respirology, Department of Medicine, University Health Network, Toronto, ON, Canada. Electronic address: n.ferguson@utoronto.ca.

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Variation intra-population › Precision Medicine and Heterogeneity of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Hétérogénéité génétique › Precision Medicine and Heterogeneity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Precision Medicine and Heterogeneity of...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Precision Medicine and Heterogeneity of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › Precision Medicine and Heterogeneity of...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Precision Medicine and Heterogeneity of...