Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial.
Astragalus propinquus
Double-Blind Method
Drugs, Chinese Herbal
/ chemistry
Exercise
/ physiology
Humans
Immune Tolerance
/ drug effects
Interleukin-4
Interleukins
/ blood
Killer Cells, Natural
Lymphocyte Count
Male
Plant Extracts
/ therapeutic use
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocytes, Regulatory
Water Sports
/ physiology
Young Adult
Astragalus Membranaceus Root
Immunosuppression
Strenuous exercise
Supplementation
Journal
Journal of the International Society of Sports Nutrition
ISSN: 1550-2783
Titre abrégé: J Int Soc Sports Nutr
Pays: United States
ID NLM: 101234168
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
28
01
2021
accepted:
22
03
2021
entrez:
17
7
2021
pubmed:
18
7
2021
medline:
28
7
2021
Statut:
epublish
Résumé
This paper aimed to verify how a supplementation of rower's diet with Astragalus Membranaceus Root (AMR) modulated their immune system response to maximal physical exertion. The double-blind study included 18 members of the Polish Rowing Team assigned to the supplemented group (n = 10), and the placebo group (n = 8). The participants performed a 2000 m test on a rowing ergometer at the beginning and at the end of the six-week of intensive training camp during which the supplemented group received 500 mg of AMR. Blood samples were obtained prior to, 1 min after completing, and 24 h after the exertion test. The levels of interleukin 2 (IL2), interleukin 4 (IL4), interleukin 10 (IL10), interferon ɤ (IFN-ɣ), and lactic acid were determined. Subpopulations of T regulatory lymphocytes [CD4+/CD25+/CD127-] (Treg), cytotoxic lymphocytes [CD8+/TCRαβ+] (CTL), natural killer cells [CD3-/CD16+/CD56+] (NK), and TCRδγ-positive cells (Tδγ) were determined with flow cytometry. After the camp, the initial NK and Treg levels sustained at the baseline, while Tδγ counts increased relative to the levels in the placebo group. In the supplemented subgroup, a decrease in IL2 level in reaction to maximal exertion clearly deepened while the change in IL-2/IL-10 level induced by the recovery after this exertion clearly increased, relative to the changes in the placebo group. AMR restored the immunological balance in strenuously trained athlets through a stabilization of NK and Treg cells with a positive trend in Tδγ towards Th1 response during restitution by cytokine IL2 modulation.
Sections du résumé
BACKGROUND
BACKGROUND
This paper aimed to verify how a supplementation of rower's diet with Astragalus Membranaceus Root (AMR) modulated their immune system response to maximal physical exertion.
METHODS
METHODS
The double-blind study included 18 members of the Polish Rowing Team assigned to the supplemented group (n = 10), and the placebo group (n = 8). The participants performed a 2000 m test on a rowing ergometer at the beginning and at the end of the six-week of intensive training camp during which the supplemented group received 500 mg of AMR. Blood samples were obtained prior to, 1 min after completing, and 24 h after the exertion test. The levels of interleukin 2 (IL2), interleukin 4 (IL4), interleukin 10 (IL10), interferon ɤ (IFN-ɣ), and lactic acid were determined. Subpopulations of T regulatory lymphocytes [CD4+/CD25+/CD127-] (Treg), cytotoxic lymphocytes [CD8+/TCRαβ+] (CTL), natural killer cells [CD3-/CD16+/CD56+] (NK), and TCRδγ-positive cells (Tδγ) were determined with flow cytometry.
RESULTS
RESULTS
After the camp, the initial NK and Treg levels sustained at the baseline, while Tδγ counts increased relative to the levels in the placebo group. In the supplemented subgroup, a decrease in IL2 level in reaction to maximal exertion clearly deepened while the change in IL-2/IL-10 level induced by the recovery after this exertion clearly increased, relative to the changes in the placebo group.
CONCLUSIONS
CONCLUSIONS
AMR restored the immunological balance in strenuously trained athlets through a stabilization of NK and Treg cells with a positive trend in Tδγ towards Th1 response during restitution by cytokine IL2 modulation.
Identifiants
pubmed: 34271953
doi: 10.1186/s12970-021-00425-5
pii: 10.1186/s12970-021-00425-5
pmc: PMC8285774
doi:
Substances chimiques
Drugs, Chinese Herbal
0
IL4 protein, human
0
Interleukins
0
Plant Extracts
0
Receptors, Antigen, T-Cell, gamma-delta
0
Interleukin-4
207137-56-2
Huang Qi
922OP8YUPF
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
57Informations de copyright
© 2021. The Author(s).
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