Serum lipid profile among sporadic and familial forms of Parkinson's disease.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
26
01
2021
accepted:
22
06
2021
entrez:
17
7
2021
pubmed:
18
7
2021
medline:
18
7
2021
Statut:
epublish
Résumé
Brain cholesterol metabolism has been described as altered in Parkinson's disease (PD) patients. Serum lipid levels have been widely studied in PD with controversial results among different populations and age groups. The present study is aimed at determining if the serum lipid profile could be influenced by the genetic background of PD patients. We included 403 PD patients (342 sporadic PD patients, 30 GBA-associated PD patients, and 31 LRRK2-associated PD patients) and 654 healthy controls (HCs). Total cholesterol, HDL, LDL, and triglycerides were measured in peripheral blood. Analysis of covariance adjusting for sex and age (ANCOVA) and post hoc tests were applied to determine the differences within lipid profiles among the groups. Multivariate ANCOVA revealed significant differences among the groups within cholesterol and LDL levels. GBA-associated PD patients had significantly lower levels of total cholesterol and LDL compared to LRRK2-associated PD patients and HCs. The different serum cholesterol levels in GBA-associated PD might be related to diverse pathogenic mechanisms. Our results support the hypothesis of lipid metabolism disruption as one of the main PD pathogenic mechanisms in patients with GBA-associated PD. Further studies would be necessary to explore their clinical implications.
Identifiants
pubmed: 34272400
doi: 10.1038/s41531-021-00206-6
pii: 10.1038/s41531-021-00206-6
pmc: PMC8285472
doi:
Types de publication
Journal Article
Langues
eng
Pagination
59Subventions
Organisme : Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)
ID : PI14/01823, PI16/01575, PI18/01898, PI19/01576
Organisme : Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)
ID : CM18/00142
Organisme : Consejería de Salud, Junta de Andalucía (Ministry of Health, Andalusian Regional Government)
ID : PI-0471-2013, PE-0210-2018, PI-0459-2018, PE-0186-2019
Organisme : Consejería de Salud, Junta de Andalucía (Ministry of Health, Andalusian Regional Government)
ID : B-0007-2019
Organisme : Ministerio de Educación, Cultura y Deporte (Ministry of Education, Culture and Sports, Spain)
ID : FPU16/05061
Informations de copyright
© 2021. The Author(s).
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