KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
16 07 2021
Historique:
received: 09 03 2021
accepted: 28 06 2021
entrez: 17 7 2021
pubmed: 18 7 2021
medline: 9 11 2021
Statut: epublish

Résumé

The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis. The regulatory subunit KCNE4 acts as an ancillary peptide of Kv1.3, modulates K

Identifiants

pubmed: 34272451
doi: 10.1038/s41598-021-94015-9
pii: 10.1038/s41598-021-94015-9
pmc: PMC8285421
doi:

Substances chimiques

Interleukin-2 0
KCNE4 protein, human 0
KCNE4 protein, mouse 0
Kv1.3 Potassium Channel 0
Potassium Channels, Voltage-Gated 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14632

Informations de copyright

© 2021. The Author(s).

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Auteurs

Albert Vallejo-Gracia (A)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.
Virology and Immunology, Gladstone Institutes, University of California San Francisco, San Francisco, CA, 94158, USA.

Daniel Sastre (D)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.

Magalí Colomer-Molera (M)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.

Laura Solé (L)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.

María Navarro-Pérez (M)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.

Jesusa Capera (J)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.

Sara R Roig (SR)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.

Oriol Pedrós-Gámez (O)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.

Irene Estadella (I)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.

Orsolya Szilágyi (O)

Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 400, 1 Egyetem Sq., Debrecen, 4032, Hungary.

Gyorgy Panyi (G)

Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 400, 1 Egyetem Sq., Debrecen, 4032, Hungary.

Péter Hajdú (P)

Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 400, 1 Egyetem Sq., Debrecen, 4032, Hungary.

Antonio Felipe (A)

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain. afelipe@ub.edu.

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Classifications MeSH