Circulating tumor cell copy-number heterogeneity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors.
Journal
NPJ precision oncology
ISSN: 2397-768X
Titre abrégé: NPJ Precis Oncol
Pays: England
ID NLM: 101708166
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
16
12
2020
accepted:
08
06
2021
entrez:
17
7
2021
pubmed:
18
7
2021
medline:
18
7
2021
Statut:
epublish
Résumé
Gatekeeper mutations are identified in only 50% of the cases at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors (TKIs). Circulating tumor cells (CTCs) are relevant tools to identify additional resistance mechanisms and can be sequenced at the single-cell level. Here, we provide in-depth investigation of copy number alteration (CNA) heterogeneity in phenotypically characterized CTCs at resistance to ALK-TKIs in ALK-positive non-small cell lung cancer. Single CTC isolation and phenotyping were performed by DEPArray or fluorescence-activated cell sorting following enrichment and immunofluorescence staining (ALK/cytokeratins/CD45/Hoechst). CNA heterogeneity was evaluated in six ALK-rearranged patients harboring ≥ 10 CTCs/20 mL blood at resistance to 1
Identifiants
pubmed: 34272470
doi: 10.1038/s41698-021-00203-1
pii: 10.1038/s41698-021-00203-1
pmc: PMC8285416
doi:
Types de publication
Journal Article
Langues
eng
Pagination
67Informations de copyright
© 2021. The Author(s).
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