Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
11
09
2020
accepted:
23
06
2021
revised:
20
05
2021
pubmed:
18
7
2021
medline:
3
2
2022
entrez:
17
7
2021
Statut:
ppublish
Résumé
Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
Identifiants
pubmed: 34272488
doi: 10.1038/s41380-021-01208-9
pii: 10.1038/s41380-021-01208-9
pmc: PMC8758471
mid: EMS128605
doi:
Substances chimiques
Chondroitin Sulfates
9007-28-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5658-5668Subventions
Organisme : Medical Research Council
ID : G1000864
Pays : United Kingdom
Organisme : European Research Council
ID : 294502
Pays : International
Organisme : Medical Research Council
ID : MR/R004463
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V002694/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_16050
Pays : United Kingdom
Organisme : Medical Research Council
ID : MRC-CIC MC-PC-16050
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S011110/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R004463/1
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
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