Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis.
Animals
Biomarkers
Cell Survival
/ genetics
Disease Models, Animal
Disease Susceptibility
Ferroptosis
/ genetics
Inflammation
/ etiology
Lipid Peroxidation
Macrophage Activation
/ immunology
Macrophages
/ immunology
Mice
Mice, Transgenic
Organ Specificity
/ immunology
Phospholipid Hydroperoxide Glutathione Peroxidase
/ genetics
Alternatively activated macrophages
ferroptosis
glutathione
glutathione peroxidase 4
inflammation
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
02
06
2021
received:
06
12
2020
accepted:
08
07
2021
pubmed:
18
7
2021
medline:
21
12
2021
entrez:
17
7
2021
Statut:
ppublish
Résumé
Acumulation of oxidized membrane lipids ultimately results in ferroptotic cell death, which can be prevented by the selenoenzyme glutathione peroxidase 4 (Gpx4). In vivo conditions promoting ferroptosis and susceptible cell types are still poorly defined. In this study, we analyzed the conditional deletion of Gpx4 in mice specifically in the myeloid cell lineages. Surprisingly, development and maintenance of LysM
Identifiants
pubmed: 34272880
doi: 10.1002/eji.202049114
pmc: PMC9290640
doi:
Substances chimiques
Biomarkers
0
Phospholipid Hydroperoxide Glutathione Peroxidase
EC 1.11.1.12
glutathione peroxidase 4, mouse
EC 1.11.1.9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2417-2429Informations de copyright
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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