Characterizing the features and course of psychiatric symptoms in children and adolescents with autoimmune encephalitis.
Anti-N-methyl-D-aspartate receptor encephalitis
Encephalitis
Paediatrics
Psychiatry
Psychopharmacology
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
21
02
2021
accepted:
04
07
2021
pubmed:
18
7
2021
medline:
7
4
2022
entrez:
17
7
2021
Statut:
ppublish
Résumé
Autoimmune encephalitis (AE) can present like a psychiatric disorder. We aimed to illustrate the psychiatric manifestations, course and management of AE in a paediatric cohort. Neuropsychiatric symptoms, investigations and treatment were retrospectively retrieved in 16 patients (mean age 11.31, SD 2.98) with an AE diagnosis at the liaison psychiatry services in two UK tertiary paediatric centres. Psychiatric presentation was characterised by an acute polysymptomatic (predominantly agitation, anger outbursts/aggressiveness, hallucinations, and emotional lability) onset. Antipsychotics produced side effects and significant worsening of symptoms in four cases, and benzodiazepines were commonly used. This psychiatric phenotype should make clinicians suspect the diagnosis of AE and carefully consider use of treatments.
Identifiants
pubmed: 34272976
doi: 10.1007/s00406-021-01293-5
pii: 10.1007/s00406-021-01293-5
pmc: PMC8938365
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
477-482Informations de copyright
© 2021. The Author(s).
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