Factors associated with orthodontic pain.

Anxiety / genetics Child Humans Orthodontic Appliances Orthodontic Appliances, Fixed Pain / genetics Surveys and Questionnaires
anxiety catastrophising ecological momentary assessment genetic polymorphisms orthodontics pain

Journal

Journal of oral rehabilitation
ISSN: 1365-2842
Titre abrégé: J Oral Rehabil
Pays: England
ID NLM: 0433604

Informations de publication

Date de publication:
Oct 2021
Historique:
revised: 09 04 2021
received: 27 10 2020
accepted: 19 06 2021
pubmed: 18 7 2021
medline: 16 9 2021
entrez: 17 7 2021
Statut: ppublish

Résumé

Pain experienced at teeth during orthodontic treatment varies largely over time, with the reasons for its interindividual variability being largely unknown: age, sex, clinical activations, psychosocial factors and genetic polymorphisms of candidate genes are putative factors that may account to explain this variability. We aimed to investigate the effect of clinical, demographic, psychological and genetic factors on pain levels experienced during fixed orthodontic treatment. A convenience sample of 183 patients undergoing full-fixed orthodontic treatment were recruited. Participant's pain levels were assessed seven times over a three-day period via a smartphone app. Clinical, demographic and psychological data were collected via questionnaires. This included the Pain Catastrophising Scale (Child version), the Corah Dental Anxiety Scale and the State and Trait Anxiety Inventory. Participants provided a DNA sample either in the form of blood or saliva, which were used for genotyping COMT gene rs6269, rs4680, rs4646310, NR3C1 gene rs2963155 and the HTR2A gene rs9316233. Bond ups had the greatest influence on perceived levels of pain experienced on teeth during orthodontic treatment, accounting for over 20% of total variance in pain response. High-pain responders had higher scores on pain catastrophising (magnification subscale). Self-reported pain during fixed orthodontic treatment was not influenced by sex, age, time into treatment, anxiety, nor by polymorphisms of COMT, HTR2A or NR3C1 genes. Pain on teeth resulting from orthodontic fixed appliances is stronger during bonds-up and in patients with high catastrophising scores. Demographics, type of clinical activations and the genetic polymorphisms investigated in this research had little or no impact on perceived pain levels.

Sections du résumé

BACKGROUND BACKGROUND
Pain experienced at teeth during orthodontic treatment varies largely over time, with the reasons for its interindividual variability being largely unknown: age, sex, clinical activations, psychosocial factors and genetic polymorphisms of candidate genes are putative factors that may account to explain this variability. We aimed to investigate the effect of clinical, demographic, psychological and genetic factors on pain levels experienced during fixed orthodontic treatment.
METHODS METHODS
A convenience sample of 183 patients undergoing full-fixed orthodontic treatment were recruited. Participant's pain levels were assessed seven times over a three-day period via a smartphone app. Clinical, demographic and psychological data were collected via questionnaires. This included the Pain Catastrophising Scale (Child version), the Corah Dental Anxiety Scale and the State and Trait Anxiety Inventory. Participants provided a DNA sample either in the form of blood or saliva, which were used for genotyping COMT gene rs6269, rs4680, rs4646310, NR3C1 gene rs2963155 and the HTR2A gene rs9316233.
RESULTS RESULTS
Bond ups had the greatest influence on perceived levels of pain experienced on teeth during orthodontic treatment, accounting for over 20% of total variance in pain response. High-pain responders had higher scores on pain catastrophising (magnification subscale). Self-reported pain during fixed orthodontic treatment was not influenced by sex, age, time into treatment, anxiety, nor by polymorphisms of COMT, HTR2A or NR3C1 genes.
CONCLUSIONS CONCLUSIONS
Pain on teeth resulting from orthodontic fixed appliances is stronger during bonds-up and in patients with high catastrophising scores. Demographics, type of clinical activations and the genetic polymorphisms investigated in this research had little or no impact on perceived pain levels.

Identifiants

DOI: 10.1111/joor.13227 PMID: 34273191 PMC: PMC9292641
pubmed: 34273191
doi: 10.1111/joor.13227
pmc: PMC9292641
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1135-1143

Subventions

Organisme : New Zealand Association of Orthodontists (ERDG/FORENZAO)
Organisme : New Zeland Dental Research Foundation

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2021 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.

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Auteurs

Wei Lin (W)

Discipline of Orthodontics, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.

Mauro Farella (M)

Discipline of Orthodontics, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.
Department of Surgical Sciences, University of Cagliari, Sardinia, Italy.
ORCID: 0000-0003-4516-647X

Joseph S Antoun (JS)

Discipline of Orthodontics, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.

Ruth K Topless (RK)

Department of Biochemistry, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.

Tony R Merriman (TR)

Department of Biochemistry, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.

Ambra Michelotti (A)

Department of Neuroscience, Reproductive Science and Oral Science, University of Naples Federico II, Naples, Italy.

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Classifications MeSH

questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Factors associated with orthodontic pain.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Factors associated with orthodontic pain.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Factors associated with orthodontic pain.
questionsmedicales.fr › Appareils orthodontiques › Factors associated with orthodontic pain.
questionsmedicales.fr › Appareils orthodontiques › Appareils dentaires fixes › Factors associated with orthodontic pain.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Factors associated with orthodontic pain.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Factors associated with orthodontic pain.